腺病毒在一步复制过程中对人干扰素的敏感性。
Adenovirus susceptibility to human interferon during one-step replication.
作者信息
Gallagher J G, Khoobyarian N
出版信息
Infect Immun. 1972 Jun;5(6):905-8. doi: 10.1128/iai.5.6.905-908.1972.
Abstract
Susceptibility of adenovirus types 2, 7, and 12 to human interferon was measured in three human diploid cell strains during a single-cycle infection. Although the relative susceptibility of adenovirus to interferon varied in these cell strains, the final yield of each type in each cell strain decreased as the interferon dose increased. On the other hand, wide difference in interferon susceptibility of adenoviruses and vesicular stomatitis virus (VSV) was noted, as interferon doses above 100 units profoundly inhibited VSV but not the adenoviruses.
摘要
在一次单周期感染期间，在三个人二倍体细胞株中测定了2型、7型和12型腺病毒对人干扰素的敏感性。尽管腺病毒对干扰素的相对敏感性在这些细胞株中有所不同，但随着干扰素剂量的增加，每个细胞株中每种类型腺病毒的最终产量均下降。另一方面，注意到腺病毒和水泡性口炎病毒（VSV）对干扰素的敏感性存在很大差异，因为高于100单位的干扰素剂量可显著抑制VSV，但对腺病毒则无此作用。
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