甲状旁腺激素、3',5'-腺苷酸、钙离子与肾糖异生作用。
Parathyroid hormone, 3'5' AMP, Ca++, and renal gluconeogenesis.
作者信息
Nagata N, Rasmussen H
出版信息
Proc Natl Acad Sci U S A. 1970 Feb;65(2):368-74. doi: 10.1073/pnas.65.2.368.
Abstract
Isolated segments of renal tubules prepared from rat kidney cortex were capable of sustained rates of gluconeogenesis when lactate served as substrate. An increase in external Ca(++), or the addition of parathyroid hormone at a fixed Ca(++) concentration led to enhanced rate of gluconeogenesis. However, parathyroid did not increase gluconeogenesis in the absence of external Ca(++) even though it caused a rise in 3'5' AMP whether Ca(++) was present or absent. Metabolite profiles showed that either an increase in external Ca(++), or the addition of hormone in the presence of calcium led to qualitatively very similar changes. However, the addition of hormone had little effect upon metabolite levels in the absence of extracellular calcium even though an increase in extracellular H(+) enhanced gluconeogenesis under similar conditions. These results are discussed in relationship to the close association of 3'5' AMP and Ca(++) in a variety of cellular systems.
摘要
从大鼠肾皮质制备的离体肾小管段，以乳酸为底物时能够维持糖异生速率。细胞外钙离子浓度增加，或在固定钙离子浓度下添加甲状旁腺激素，会导致糖异生速率加快。然而，即使无论有无钙离子存在甲状旁腺激素都会使3',5'-环磷酸腺苷（3',5' AMP）水平升高，但在没有细胞外钙离子的情况下，甲状旁腺激素并不会增加糖异生。代谢物谱显示，细胞外钙离子浓度增加，或在有钙存在时添加激素，会导致在性质上非常相似的变化。然而，在没有细胞外钙的情况下，添加激素对代谢物水平影响很小，尽管在类似条件下细胞外氢离子浓度增加会增强糖异生。结合3',5' AMP和钙离子在多种细胞系统中的紧密联系对这些结果进行了讨论。
相似文献
1
Parathyroid hormone, 3'5' AMP, Ca++, and renal gluconeogenesis.甲状旁腺激素、3',5'-腺苷酸、钙离子与肾糖异生作用。
Proc Natl Acad Sci U S A. 1970 Feb;65(2):368-74. doi: 10.1073/pnas.65.2.368.
2
Renal gluconeogenesis: effects of parathyroid hormone and dibutyryl 3',5'-AMP.肾糖异生：甲状旁腺激素和二丁酰3',5'-腺苷酸的作用
Biochim Biophys Acta. 1970 Jul 21;215(1):17-28. doi: 10.1016/0304-4165(70)90383-1.
3
Ionic control of renal gluconeogenesis. IV. Effect of extracellular phosphate concentration.肾脏糖异生的离子调控。IV. 细胞外磷酸盐浓度的影响。
Biochim Biophys Acta. 1973 Jun 20;313(1):59-71. doi: 10.1016/0304-4165(73)90188-8.
4
Ionic control of renal gluconeogenesis. II. The effects of Ca2+ and H+ upon the response to parathyroid hormone and cyclic AMP.肾糖异生的离子调控。II. 钙和氢离子对甲状旁腺激素及环磷酸腺苷反应的影响。
Biochim Biophys Acta. 1973 Jun 20;313(1):32-41. doi: 10.1016/0304-4165(73)90186-4.
5
Substrate-dependent effect of 1-34 human parathyroid hormone fragment, dibutyryl cAMP and cAMP on gluconeogenesis in rabbit renal tubules.1-34人甲状旁腺激素片段、二丁酰环磷腺苷和环磷腺苷对兔肾小管糖异生的底物依赖性作用。
Biochim Biophys Acta. 1986 May 29;886(3):483-90. doi: 10.1016/0167-4889(86)90185-0.
6
Effect of adenosine 3',5'-monophosphate on production of glucose and ammonia by renal cortex.3',5'-环磷酸腺苷对肾皮质葡萄糖和氨生成的影响。
J Clin Invest. 1969 Aug;48(8):1408-12. doi: 10.1172/JCI106106.
7
The effect of cyclic nucleotides on glucose synthesis in isolated rat kidney tubules.环核苷酸对离体大鼠肾小管葡萄糖合成的影响。
Hoppe Seylers Z Physiol Chem. 1970 Mar;351(3):291-2.
8
Effect of P2Y-purinoceptor stimulation on renal gluconeogenesis in rats.P2Y嘌呤受体刺激对大鼠肾脏糖异生的影响。
Biochem Biophys Res Commun. 1995 Jun 15;211(2):454-61. doi: 10.1006/bbrc.1995.1835.
9
The role of calcium in renal gluconeogenesis: studies using ionophore A23187.钙在肾脏糖异生中的作用：使用离子载体A23187的研究
Curr Probl Clin Biochem. 1977;8:318-28.
10
Metabolism of isolated kidney tubules. Additive effects of parathyroid hormone and free-fatty acids on renal gluconeogenesis.
Eur J Biochem. 1972 Nov 21;31(1):69-79. doi: 10.1111/j.1432-1033.1972.tb02502.x.
引用本文的文献
1
Calreticulin-Enigmatic Discovery.钙网织蛋白之谜的惊人发现
Biomolecules. 2024 Jul 19;14(7):866. doi: 10.3390/biom14070866.
2
Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization.内源性肾脂联素通过增强丙酮酸和脂肪酸利用来驱动糖异生。
Nat Commun. 2023 Oct 17;14(1):6531. doi: 10.1038/s41467-023-42188-4.
3
STC1 and PTHrP Modify Carbohydrate and Lipid Metabolism in Liver of a Teleost Fish.STC1 和 PTHrP 改变鱼类肝脏中的碳水化合物和脂质代谢。
Sci Rep. 2019 Jan 24;9(1):723. doi: 10.1038/s41598-018-36821-2.
4
Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7.蛋白激酶 CK2 通过磷酸化锌通道 ZIP7 触发细胞质锌信号通路。
Sci Signal. 2012 Feb 7;5(210):ra11. doi: 10.1126/scisignal.2002585.
5
Gluconeogenesis from glutamine and lactate in the isolated human renal proximal tubule: longitudinal heterogeneity and lack of response to adrenaline.在分离的人肾近端小管中由谷氨酰胺和乳酸生成葡萄糖：纵向异质性及对肾上腺素无反应
Biochem J. 2001 Dec 1;360(Pt 2):371-7. doi: 10.1042/0264-6021:3600371.
6
The relationship between the actions of vitamin D, parathyroid hormone and calcitonin.维生素D、甲状旁腺激素和降钙素的作用之间的关系。
Calcif Tissue Res. 1971;6(4):265-79. doi: 10.1007/BF02196208.
7
Modulation of experimental renal dysfunction of hereditary fructose intolerance by circulating parathyroid hormone.循环甲状旁腺激素对遗传性果糖不耐受实验性肾功能障碍的调节作用。
Proc Natl Acad Sci U S A. 1971 Jan;68(1):132-5. doi: 10.1073/pnas.68.1.132.
8
[Cyclic adenosine monophosphate and renal failure (author's transl)].环磷酸腺苷与肾衰竭（作者译）
Klin Wochenschr. 1974 Dec 15;52(24):1175-6. doi: 10.1007/BF01466737.
9
Pathogenic role of cyclic AMP in the impairment of urinary concentrating ability in acute hypercalcemia.环磷酸腺苷在急性高钙血症导致尿浓缩功能损害中的致病作用。
J Clin Invest. 1974 Nov;54(5):1049-55. doi: 10.1172/JCI107848.
10
Study of the renal tubular interactions of thyrocalcitonin, cyclic adenosine 3',5'-monophosphate, 25-hydroxycholecalciferol, and calcium ion.甲状腺降钙素、环磷酸腺苷、25-羟胆钙化醇及钙离子的肾小管相互作用研究
J Clin Invest. 1974 Mar;53(3):756-67. doi: 10.1172/JCI107614.
本文引用的文献
1
THE ACTION OF EPINEPHRINE AND THE ROLE OF THE ADENYL CYCLASE SYSTEM IN HORMONE ACTION.肾上腺素的作用及腺苷酸环化酶系统在激素作用中的角色。
Recent Prog Horm Res. 1965;21:623-46.
2
A FLUOROMETRIC METHOD FOR THE ENZYMIC DETERMINATION OF GLYCOLYTIC INTERMEDIATES.一种用于酶法测定糖酵解中间产物的荧光测定法。
Anal Biochem. 1964 Apr;7:472-84. doi: 10.1016/0003-2697(64)90156-3.
3
Renal gluconeogenesis. The effect of diet on the gluconeogenic capacity of rat-kidney-cortex slices.肾糖异生。饮食对大鼠肾皮质切片糖异生能力的影响。
Biochem J. 1963 Jan;86(1):22-7. doi: 10.1042/bj0860022.
4
Further studies on the isolation and charcterization of parathyroid polypeptides.甲状旁腺多肽的分离与特性的进一步研究。
Biochemistry. 1966 Jan;5(1):344-52. doi: 10.1021/bi00865a044.
5
Renal gluconeogenesis in acidosis, alkalosis, and potassium deficiency: its possible role in regulation of renal ammonia production.酸中毒、碱中毒和钾缺乏时的肾糖异生：其在调节肾氨生成中的可能作用。
J Clin Invest. 1966 Apr;45(4):612-9. doi: 10.1172/JCI105375.
6
Regulation of glutamine metabolism in vitro by bicarbonate ion and pH.体外碳酸氢根离子和pH对谷氨酰胺代谢的调节
J Clin Invest. 1969 Jun;48(6):1088-96. doi: 10.1172/JCI106065.
7
Renal adenyl cyclase: anatomically separate sites for parathyroid hormone and vasopressin.肾腺苷酸环化酶：甲状旁腺激素和血管加压素的解剖学上分开的作用位点。
Science. 1968 Feb 2;159(3814):545-7. doi: 10.1126/science.159.3814.545.
8
Effect of EDTA on electrophoretic mobility of slime mould cells and its relationship to current theories of cell adhesion.乙二胺四乙酸对黏菌细胞电泳迁移率的影响及其与当前细胞黏附理论的关系。
Nature. 1969 Jan 11;221(5176):192-3. doi: 10.1038/221192a0.
9
Effects of purified parathyroid hormone on the calcium metabolism of monkey kidney cells.纯化甲状旁腺激素对猴肾细胞钙代谢的影响。
Endocrinology. 1968 Dec;83(6):1316-22. doi: 10.1210/endo-83-6-1316.
10
Calcium metabolism in HeLa cells and the effects of parathyroid hormone.HeLa细胞中的钙代谢及甲状旁腺激素的作用
J Cell Biol. 1968 Mar;36(3):567-82. doi: 10.1083/jcb.36.3.567.
Zotero 插件