Mazure C, Gershon E S
Arch Gen Psychiatry. 1979 May;36(5):521-5. doi: 10.1001/archpsyc.1979.01780050031002.
Confidence in the assignment of lifetime psychiatric diagnosis is of great importance to genetic studies of psychiatric illness. To establish the credibility of a lifetime psychiatric history obtained via a structured interview, two paradigms were constructed to estimate reproducibility of the interview recording process. The first paradigm, simultaneous coding, was used to test comparability of four interviewers independently coding an interview form. Low variance/high reliability was demonstrated. The second paradigm, test-retest, provided for each subject to be interviewed twice, with a mean interim time of 6.7 months (SEM = .39). This paradigm demonstrated high reproducibility of psychiatric diagnosis over time. The overall k value for measurement of diagnostic agreement was .79. Only the diagnostic category of minor depression seemed to evade reliability. It was shown across both paradigms that an interviewer need not be blind (naive to previously held diagnosis) to obtain an unbiased interview. However, it is still recommended that the diagnosis of each interview should be determined by an independent diagnostician.
对终身精神疾病诊断的赋值信心对于精神疾病的遗传学研究至关重要。为了确立通过结构化访谈获得的终身精神病史的可信度，构建了两种范式来评估访谈记录过程的可重复性。第一种范式，即同步编码，用于测试四名访谈者对访谈表格进行独立编码的可比性。结果显示方差低/可靠性高。第二种范式，即重测，要求对每个受试者进行两次访谈，平均间隔时间为6.7个月（标准误=0.39）。该范式表明精神疾病诊断随时间具有高度可重复性。诊断一致性测量的总体k值为0.79。只有轻度抑郁症的诊断类别似乎缺乏可靠性。在两种范式中均表明，访谈者无需不知情（对先前的诊断不知情）即可获得无偏差的访谈。然而，仍建议每次访谈的诊断应由独立的诊断医生确定。
