Holloway C J, Brunner G, Schmidt E, Schmidt F W
Artif Organs. 1979 Feb;3(1):15-9. doi: 10.1111/j.1525-1594.1979.tb03798.x.
The plasma concentrations of methane and ethane thiols have been determined during the course of acute liver failure by a gas-chromatographic technique, and a prognostic evaluation is possible using this analysis. Further, the effects of some therapeutic measures, notably hemoperfusion, on the thiol levels have been investigated. It is concluded that these toxins, which are to a large extent covalently protein-bound, are extremely difficult to remove in an extracorporeal liver support system. Since the cause of the pathological thiol concentrations is probably the elevated plasma methionine levels associated with severe liver disease, it is suggested that the most hopeful course of action against the accumulation of thiols in the body might be a preventative therapy involving the normalization of methionine at an early stage of the disease.
采用气相色谱技术测定了急性肝衰竭病程中血浆甲硫醇和乙硫醇的浓度，并可利用该分析进行预后评估。此外，还研究了一些治疗措施，特别是血液灌流对硫醇水平的影响。得出的结论是，这些在很大程度上与蛋白质共价结合的毒素，在体外肝脏支持系统中极难清除。由于病理性硫醇浓度的原因可能是与严重肝病相关的血浆蛋氨酸水平升高，因此建议针对体内硫醇蓄积最有希望的行动方案可能是在疾病早期进行预防性治疗，使蛋氨酸水平正常化。
