豚鼠疱疹样病毒感染。II. 小鼠和兔子的抗体反应及病毒持续性
Guinea pig herpes-like virus infections. II. Antibody response and virus persistence in mice and rabbits.
作者信息
Lam K M, Hsiung G D
出版信息
Infect Immun. 1973 Mar;7(3):432-7. doi: 10.1128/iai.7.3.432-437.1973.
Mice inoculated with guinea pig herpes-like virus produced minimal, if any, antibody response, and no virus was isolated from the inoculated animals 64 days after administration. The antibody response in rabbits inoculated with the same virus was prompt and reached a high level within 14 to 29 days regardless of the site of inoculation. Long-term persistence of viremia was observed only in intravenously inoculated rabbits; a brief period of viremia was observed in intraperitoneally inoculated rabbits, but no viremia was obtained in rabbits inoculated by the subcutaneous route. Maternal antibody was transferred readily to offspring; however, transference of infectious virus from mother to offspring was demonstrable in only one of 75 fetuses tested.
接种豚鼠疱疹样病毒的小鼠产生的抗体反应极少（即便有也微乎其微），给药64天后，接种动物体内未分离出病毒。接种相同病毒的兔子抗体反应迅速，无论接种部位如何，在14至29天内抗体水平都会达到很高。仅在静脉接种的兔子中观察到病毒血症的长期持续存在；在腹腔接种的兔子中观察到了短暂的病毒血症期，但皮下接种的兔子未出现病毒血症。母源抗体很容易转移给后代；然而，在75只接受检测的胎儿中，只有一只证明有传染性病毒从母体转移给了后代。
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