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豚鼠疱疹样病毒感染。II. 小鼠和兔子的抗体反应及病毒持续性

Guinea pig herpes-like virus infections. II. Antibody response and virus persistence in mice and rabbits.

作者信息

Lam K M, Hsiung G D

出版信息

Infect Immun. 1973 Mar;7(3):432-7. doi: 10.1128/iai.7.3.432-437.1973.

DOI:10.1128/iai.7.3.432-437.1973
PMID:4351587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422696/
Abstract

Mice inoculated with guinea pig herpes-like virus produced minimal, if any, antibody response, and no virus was isolated from the inoculated animals 64 days after administration. The antibody response in rabbits inoculated with the same virus was prompt and reached a high level within 14 to 29 days regardless of the site of inoculation. Long-term persistence of viremia was observed only in intravenously inoculated rabbits; a brief period of viremia was observed in intraperitoneally inoculated rabbits, but no viremia was obtained in rabbits inoculated by the subcutaneous route. Maternal antibody was transferred readily to offspring; however, transference of infectious virus from mother to offspring was demonstrable in only one of 75 fetuses tested.

摘要

接种豚鼠疱疹样病毒的小鼠产生的抗体反应极少(即便有也微乎其微),给药64天后,接种动物体内未分离出病毒。接种相同病毒的兔子抗体反应迅速,无论接种部位如何,在14至29天内抗体水平都会达到很高。仅在静脉接种的兔子中观察到病毒血症的长期持续存在;在腹腔接种的兔子中观察到了短暂的病毒血症期,但皮下接种的兔子未出现病毒血症。母源抗体很容易转移给后代;然而,在75只接受检测的胎儿中,只有一只证明有传染性病毒从母体转移给了后代。

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引用本文的文献

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Microbiol Rev. 1980 Sep;44(3):468-90. doi: 10.1128/mr.44.3.468-490.1980.

本文引用的文献

1
Guinea pig leukocytes: in vivo and in vitro infection with a herpes-like virus.
J Immunol. 1971 Jan;106(6):1686-9.
2
Isolation and characterization of a herpes-like virus from New Zealand albino rabbit kidney cell cultures: a probable reisolation of virus 3 of Rivers.从新西兰白兔肾细胞培养物中分离和鉴定一种类疱疹病毒:可能再次分离出里弗斯病毒3型
J Virol. 1969 Jan;3(1):59-69. doi: 10.1128/JVI.3.1.59-69.1969.
3
Infection of thymus cells in vivo and in vitro with a guinea pig herpes-like virus and the effect of antibody on virus replication in organ culture.豚鼠类疱疹病毒对胸腺细胞的体内外感染及抗体对器官培养中病毒复制的影响。
J Immunol. 1973 Feb;110(2):552-60.
4
Further studies on the mode of transmission of herpes-like virus in guinea pigs.豚鼠中类疱疹病毒传播方式的进一步研究。
Proc Soc Exp Biol Med. 1971 Nov;138(2):422-6. doi: 10.3181/00379727-138-35911.
5
Herpes-like virus of the guinea pig: propagation in brain tissue of guinea pigs and mice.豚鼠疱疹样病毒:在豚鼠和小鼠脑组织中的增殖
J Infect Dis. 1971 Mar;123(3):284-91. doi: 10.1093/infdis/123.3.284.
6
Herpesvirus infection of guinea pigs. II. Transplacental transmission.豚鼠的疱疹病毒感染。II. 经胎盘传播。
Am J Epidemiol. 1971 Apr;93(4):308-13. doi: 10.1093/oxfordjournals.aje.a121262.
7
Herpesvirus infection of guinea pigs. I. Isolation, characterization and pathogenicity.豚鼠的疱疹病毒感染。I. 分离、鉴定及致病性。
Am J Epidemiol. 1971 Apr;93(4):298-307. doi: 10.1093/oxfordjournals.aje.a121261.