Stent G S
Proc Natl Acad Sci U S A. 1973 Apr;70(4):997-1001. doi: 10.1073/pnas.70.4.997.
Hebb's postulate of learning envisages that activation or inactivation of extant synaptic contacts in plastic neural networks depends on the synchronous impulse activity of pre- and postsynaptic nerve cells. The physiological mechanism proposed here for this process posits that at synapses acting according to Hebb's postulate, the receptors for the neurotransmitter are eliminated from the postsynaptic membrane by the transient reversals of the sign of membrane polarization that occur during action potential impulses in the postsynaptic cell. But, since the release of neurotransmitter drives the membrane potential of the synaptic zone towards a level about half-way between the negative-inside resting potential and the positive-inside action potential, it would follow that the membrane patches surrounding the receptors of a synapse whose activity has contributed to setting off the postsynaptic impulse would be spared the full extent of the noxious polarity reversal. This mechanism can account for a neurophysiologically documented example of the operation of Hebb's postulate, namely the plasticity of the connections between fourth- and fifth-order neurons in the visual cortex of cats.
赫布提出的学习假设设想，在可塑性神经网络中，现存突触联系的激活或失活取决于突触前和突触后神经细胞的同步冲动活动。这里提出的这一过程的生理机制假定，在按照赫布假设起作用的突触处，神经递质的受体通过突触后细胞动作电位冲动期间发生的膜极化符号的短暂反转，从突触后膜上被清除。但是，由于神经递质的释放会将突触区的膜电位驱动到介于膜内负静息电位和膜内正动作电位之间约一半的水平，那么可以推断，其活动促成引发突触后冲动的突触受体周围的膜片，将不会完全经历有害的极性反转。这一机制能够解释一个神经生理学上有记录的赫布假设运作的例子，即猫视觉皮层中第四级和第五级神经元之间连接的可塑性。
