Leclercq G, Heuson J C, Deboel M C, Mattheiem W H
Br Med J. 1975 Jan 25;1(5951):185-9. doi: 10.1136/bmj.1.5951.185.
Oestrogen receptors were found in 156 (73%) out of 214 primary breast cancers and in 98 (58%) out of 168 metastatic deposits. These proportions reached 82% and 70% respectively in the second half of the study. Receptors were not found in samples of normal breast tissue but small amounts were present in tissue from some hyperplastic lesions and in male gynaecomastia. Receptor concentrations in the malignant samples were evenly distributed over a wide range of values, suggesting that even "negative" tumours might contain trace amounts undetectable by the method used. Each tumour was characterized by a given level of receptor concentration. In most cases the amounts found in the invaded axillary nodes and their corresponding primary tumours were the same. We suggest that quantitative rather than qualitative assessment should provide an appropriate criterion for studies of biochemical and clinical correlations.
在214例原发性乳腺癌中，有156例（73%）发现雌激素受体；在168处转移灶中，有98例（58%）发现雌激素受体。在研究的后半期，这些比例分别达到了82%和70%。在正常乳腺组织样本中未发现受体，但在一些增生性病变组织和男性乳腺增生组织中存在少量受体。恶性样本中的受体浓度在很宽的数值范围内均匀分布，这表明即使是“阴性”肿瘤也可能含有该检测方法无法检测到的痕量受体。每个肿瘤都有特定水平的受体浓度特征。在大多数情况下，在受累腋窝淋巴结及其相应原发性肿瘤中发现的受体量是相同的。我们认为，定量而非定性评估应为生化与临床相关性研究提供合适的标准。
