急性和慢性给予硝基咪唑后小鼠神经传导速度的变化
Changes in nerve conduction velocity in the mouse after acute and chronic administration of nitroimidazoles.
作者信息
Hirst D G, Vojnovic B, Hobson B
出版信息
Br J Cancer. 1979 Feb;39(2):159-67. doi: 10.1038/bjc.1979.26.
The effect of the nitroimidazoles misonidazole, Ro-05-9963, RGW-608 and metronidazole on nerve conduction velocity (NCV) were measured in the anaesthetized mouse. The compounds were administered by i.p. injection either as a single dose of 1 mg/g (only 0.5 mg/g for RGW-608) or in 36 fractions of 0.15 mg/g over 18 days (only 4 fractions in 2 days for RGW-608). After single doses a reduction in nerve conduction velocity was seen with all the compounds except metronidazole, which had no significant effect. During chronic exposure, a reduction in NCV occurred towards the end of the course of injections. All compounds produced an effect, although RGW-608 was the most neurotoxic, giving the largest reduction in NCV after only 4 injections. After the end of chronic exposure to misonidazole, Ro-05-9963 and metronidazole, recovery to normal took 2-3 weeks.
在麻醉小鼠中测定了硝基咪唑类药物米索硝唑、Ro-05-9963、RGW-608和甲硝唑对神经传导速度（NCV）的影响。这些化合物通过腹腔注射给药，单次剂量为1 mg/g（RGW-608仅为0.5 mg/g），或在18天内分36次注射，每次0.15 mg/g（RGW-608在2天内仅分4次注射）。单次给药后，除甲硝唑无显著影响外，所有化合物均使神经传导速度降低。在慢性暴露期间，注射过程接近尾声时神经传导速度出现下降。所有化合物均产生了影响，尽管RGW-608神经毒性最大，仅4次注射后神经传导速度下降幅度最大。在慢性暴露于米索硝唑、Ro-05-9963和甲硝唑结束后，恢复正常需要2至3周。
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