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胚胎细胞对质膜的特异性识别。

Specific recognition of plasma membranes by embryonic cells.

作者信息

Merrell R, Glaser L

出版信息

Proc Natl Acad Sci U S A. 1973 Oct;70(10):2794-8. doi: 10.1073/pnas.70.10.2794.

Abstract

Methods have been developed for preparation of plasma membrane fractions from embryonic neural retina and cerebellum. These membrane fractions are specifically bound by intact cells of the original tissue (homotypic binding) and not by cells from the other tissue (heterotypic binding). Aggregation of neural retina cells and cerebellar cells is prevented by addition of homotypic membranes but not by heterotypic membranes. We conclude that, under our assay conditions, these embryonic cells specifically recognize homotypic membranes, and that the specificity of recognition is the same as in the initial step in the process of cellular aggregation.

摘要

已经开发出从胚胎神经视网膜和小脑中制备质膜组分的方法。这些膜组分被原始组织的完整细胞特异性结合(同型结合),而不被其他组织的细胞结合(异型结合)。添加同型膜可防止神经视网膜细胞和小脑细胞聚集,而异型膜则不能。我们得出结论,在我们的检测条件下,这些胚胎细胞特异性识别同型膜,并且识别的特异性与细胞聚集过程初始步骤中的相同。

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