File S E, Bond A J
Psychopharmacology (Berl). 1979;66(3):309-13. doi: 10.1007/BF00428325.
In a double-blind cross-over study using normal student volunteers, the effects of 1 and 2.5 mg lorazepam on self-rated mood and bodily symptoms, as well as performance in a number of tests were assessed. Both doses significantly increased self ratings of physical and mental sedation, the effects being more marked 4 h after drug administration than after 1 h. Lorazepam impaired simple reaction time, verbal learning, number cancellation, symbol copying and performance in the digit-symbol substitution test. The impairments were greater with the 2.5 mg dose and were more marked 4 h after drug administration than after 1 h.
在一项使用正常学生志愿者的双盲交叉研究中，评估了1毫克和2.5毫克劳拉西泮对自评情绪和身体症状的影响，以及在多项测试中的表现。两种剂量均显著提高了身体和精神镇静的自评分数，给药后4小时的效果比1小时后更明显。劳拉西泮损害了简单反应时间、言语学习、数字划消、符号抄写以及数字符号替换测试中的表现。2.5毫克剂量的损害更大，给药后4小时的损害比1小时后更明显。
