File S E, Silverstone T
Psychopharmacology (Berl). 1981;74(4):353-4. doi: 10.1007/BF00432746.
The effects of single intravenous doses of naloxone (0.8 and 1.6 mg) in a variety of performance tasks and on subjective ratings of mood and bodily symptoms were investigated in 12 student volunteers. Naloxone was without effect on any of the performance measures. However, 5 min after naloxone (1.6 mg) the subjects felt significantly more troubled, mentally slow, incompetent, withdrawn and physically tired, and less irritable. These effects appeared to be dose-related since 0.8 mg produced similar, but not statistically significant changes. Sixty-five minutes after the higher dose subjects felt significantly more muzzy and incompetent; in contrast to the effects at 5 min they now felt significantly more irritable. These results are difficult to explain solely in terms of opiate receptor blockade.
在12名学生志愿者中研究了单次静脉注射纳洛酮（0.8毫克和1.6毫克）对各种行为任务以及情绪和身体症状主观评分的影响。纳洛酮对任何行为指标均无影响。然而，注射1.6毫克纳洛酮5分钟后，受试者感觉明显更烦恼、思维迟缓、能力不足、孤僻和身体疲劳，且易怒程度降低。这些效应似乎与剂量相关，因为0.8毫克产生了类似但无统计学意义的变化。高剂量注射65分钟后，受试者感觉明显更迷糊和能力不足；与5分钟时的效应相反，此时他们感觉易怒程度明显增加。这些结果很难仅用阿片受体阻断来解释。
