Aaronson S A
Proc Natl Acad Sci U S A. 1971 Dec;68(12):3069-72. doi: 10.1073/pnas.68.12.3069.
Focus-forming virus can be induced by chemicals from virus-negative clonal lines of cells transformed by murine sarcoma virus. The viruses activated from such nonproducer cells have the host range and serologic properties of endogenous helper viruses of the cells rather than those of the sarcoma virus used to transform them. The evidence indicates that murine sarcoma virus-transformed nonproducer cells of two species contain the genetic information for both murine sarcoma and helper virus production in an unexpressed form.
聚焦形成病毒可由来自经鼠肉瘤病毒转化的病毒阴性细胞克隆系的化学物质诱导产生。从这类非生产性细胞激活的病毒具有细胞内源性辅助病毒的宿主范围和血清学特性,而非用于转化它们的肉瘤病毒的特性。证据表明,两种物种经鼠肉瘤病毒转化的非生产性细胞含有以未表达形式存在的鼠肉瘤和辅助病毒产生的遗传信息。