广泛自然存在针对一类特定内源性小鼠C型病毒的高滴度中和抗体。
Widespread natural occurrence of high titers of neutralizing antibodies to a specific class of endogenous mouse type-C virus.
作者信息
Aaronson S A, Stephenson J R
出版信息
Proc Natl Acad Sci U S A. 1974 May;71(5):1957-61. doi: 10.1073/pnas.71.5.1957.
Abstract
Mouse cells contain several biologically distinguishable endogenous type-C viruses. In the present studies, the immunologic response of different strains of mice to the natural expression of these viruses has been examined. High titers of neutralizing antibodies have been detected to a class of virus that lacks the ability to exogenously infect mouse cells. The expression of this virus, in vivo as well as in vitro, is shown to be vertically transmitted as a dominant genetic trait. The findings indicate the widespread occurrence of this endogenous virus and the ability of the mouse to immunologically respond to a class of type-C virus whose mode of transmission is similar to that of cellular genes.
摘要
小鼠细胞含有几种生物学上可区分的内源性C型病毒。在本研究中，已检测了不同品系小鼠对这些病毒自然表达的免疫反应。已检测到针对一类缺乏外源性感染小鼠细胞能力的病毒的高滴度中和抗体。这种病毒在体内和体外的表达均显示为作为显性遗传性状垂直传播。这些发现表明这种内源性病毒广泛存在，以及小鼠对一类传播方式与细胞基因相似的C型病毒产生免疫反应的能力。
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