2-脱氧-D-葡萄糖对水疱性口炎病毒和新城疫病毒增殖的抑制作用
Inhibition of the multiplication of vesicular stomatitis and Newcastle disease virus by 2-deoxy-d-glucose.
作者信息
Scholtissek C, Rott R, Hau G, Kaluza G
出版信息
J Virol. 1974 Jun;13(6):1186-93. doi: 10.1128/JVI.13.6.1186-1193.1974.
Abstract
The production of infectious vesicular stomatitis (VSV) and Newcastle disease virus can be completely inhibited by 2-deoxy-d-glucose in pyruvate-containing medium, if virus either grown in pyruvate-containing medium or dialyzed against phosphate-buffered saline is used for infection. Under these conditions, the synthesis of all VSV proteins is reduced. VSV RNA, which is synthesized at reduced rates, seems to be unstable. The effect is completely reversible. If virus grown in glucose-containing medium is used for infection, the production of both viruses is not significantly inhibited by 2-deoxy-d-glucose. Under these conditions the production of the VSV glycoprotein is specifically impaired, but does not lead to a marked reduction of the yield of infectious virus.
摘要
在含有丙酮酸的培养基中，若使用在含丙酮酸培养基中生长或用磷酸盐缓冲盐水透析过的病毒进行感染，传染性水疱性口炎病毒（VSV）和新城疫病毒的产生可被2-脱氧-D-葡萄糖完全抑制。在这些条件下，所有VSV蛋白的合成都会减少。以较低速率合成的VSV RNA似乎不稳定。这种作用是完全可逆的。若使用在含葡萄糖培养基中生长的病毒进行感染，2-脱氧-D-葡萄糖对这两种病毒的产生没有显著抑制作用。在这些条件下，VSV糖蛋白的产生受到特异性损害，但不会导致感染性病毒产量的显著降低。
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