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J Virol. 1974 Jun;13(6):1186-93. doi: 10.1128/JVI.13.6.1186-1193.1974.
2
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Effect of 2-deoxy-D-glucose on the multiplication of Semliki Forest virus and the reversal of the block by mannose.2-脱氧-D-葡萄糖对塞姆利基森林病毒增殖的影响以及甘露糖对该阻断作用的逆转
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The case for re-examining glycosylation inhibitors, mimetics, primers and glycosylation decoys as antivirals and anti-inflammatories in COVID19.重新审视糖基化抑制剂、模拟物、引物和糖基化诱饵作为COVID-19抗病毒和抗炎药物的理由。
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Morphological and biochemical characterization of viral particles produced by the tsO45 mutant of vesicular stomatitis virus at restrictive temperature.水疱性口炎病毒tsO45突变体在限制温度下产生的病毒颗粒的形态学和生化特征
J Virol. 1979 Jan;29(1):185-95. doi: 10.1128/JVI.29.1.185-195.1979.
8
Tunicamycin inhibits glycosylation and multiplication of Sindbis and vesicular stomatitis viruses.衣霉素抑制辛德毕斯病毒和水疱性口炎病毒的糖基化及增殖。
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9
Effects of 2-deoxyglucose, glucosamine, and mannose on cell fusion and the glycoproteins of herpes simplex virus.2-脱氧葡萄糖、氨基葡萄糖和甘露糖对细胞融合及单纯疱疹病毒糖蛋白的影响
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Biological and physical modifications of a murine oncornavirus by 2-deoxy-D-glucose.2-脱氧-D-葡萄糖对鼠类肿瘤病毒的生物学和物理修饰
J Virol. 1975 Jun;15(6):1323-31. doi: 10.1128/JVI.15.6.1323-1331.1975.

本文引用的文献

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Inhibition of influenza virus multiplication with a glucose antimetabolite (2-deoxy-D-glucose).用葡萄糖抗代谢物（2-脱氧-D-葡萄糖）抑制流感病毒增殖。
Nature. 1959 Jan 24;183(4656):271-2. doi: 10.1038/183271b0.
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Hydrogen ion buffers for biological research.用于生物学研究的氢离子缓冲剂。
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Synthesis in vitro of RNA complementary to parental viral RNA by RNA polymerase induced by influenza virus.流感病毒诱导的RNA聚合酶在体外合成与亲本病毒RNA互补的RNA。
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Synthesis in vivo of influenza virus plus and minus strand RNA and its preferential inhibition by antibiotics.流感病毒正链和负链RNA的体内合成及其被抗生素的优先抑制作用。
Virology. 1970 Apr;40(4):989-96. doi: 10.1016/0042-6822(70)90145-5.
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
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Effect of temperature on the multiplication of an Influenza virus.
J Gen Virol. 1969 Sep;5(2):283-90. doi: 10.1099/0022-1317-5-2-283.
7
Detection of an unstable RNA in chick fibroblasts after reduction of the UTP pool by glucosamine.在通过氨基葡萄糖降低UTP库后检测鸡成纤维细胞中不稳定的RNA。
Eur J Biochem. 1971 Dec;24(2):358-65. doi: 10.1111/j.1432-1033.1971.tb19694.x.
8
Effect of 2-deoxy-D-glucose on the multiplication of Semliki Forest virus and the reversal of the block by mannose.2-脱氧-D-葡萄糖对塞姆利基森林病毒增殖的影响以及甘露糖对该阻断作用的逆转
Virology. 1973 Jul;54(1):179-89. doi: 10.1016/0042-6822(73)90127-x.
9
Inhibition of influenza viral glycoprotein synthesis by sugars.糖类对流感病毒糖蛋白合成的抑制作用。
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10
Inhibition of glycoprotein biosynthesis of influenza virus by D-glucosamine and 2-deoxy-D-glucose.D-葡萄糖胺和2-脱氧-D-葡萄糖对流感病毒糖蛋白生物合成的抑制作用。
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2-脱氧-D-葡萄糖对水疱性口炎病毒和新城疫病毒增殖的抑制作用

Inhibition of the multiplication of vesicular stomatitis and Newcastle disease virus by 2-deoxy-d-glucose.

作者信息

Scholtissek C, Rott R, Hau G, Kaluza G

出版信息

J Virol. 1974 Jun;13(6):1186-93. doi: 10.1128/JVI.13.6.1186-1193.1974.

DOI:10.1128/JVI.13.6.1186-1193.1974
PMID:4364895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC355437/
Abstract

The production of infectious vesicular stomatitis (VSV) and Newcastle disease virus can be completely inhibited by 2-deoxy-d-glucose in pyruvate-containing medium, if virus either grown in pyruvate-containing medium or dialyzed against phosphate-buffered saline is used for infection. Under these conditions, the synthesis of all VSV proteins is reduced. VSV RNA, which is synthesized at reduced rates, seems to be unstable. The effect is completely reversible. If virus grown in glucose-containing medium is used for infection, the production of both viruses is not significantly inhibited by 2-deoxy-d-glucose. Under these conditions the production of the VSV glycoprotein is specifically impaired, but does not lead to a marked reduction of the yield of infectious virus.

摘要

在含有丙酮酸的培养基中，若使用在含丙酮酸培养基中生长或用磷酸盐缓冲盐水透析过的病毒进行感染，传染性水疱性口炎病毒（VSV）和新城疫病毒的产生可被2-脱氧-D-葡萄糖完全抑制。在这些条件下，所有VSV蛋白的合成都会减少。以较低速率合成的VSV RNA似乎不稳定。这种作用是完全可逆的。若使用在含葡萄糖培养基中生长的病毒进行感染，2-脱氧-D-葡萄糖对这两种病毒的产生没有显著抑制作用。在这些条件下，VSV糖蛋白的产生受到特异性损害，但不会导致感染性病毒产量的显著降低。