甲基柔红糖胺对单纯疱疹病毒复制的抑制作用
Inhibition of herpes simplex virus replication by methyl daunosamine.
作者信息
Spivack J G, Prusoff W H, Tritton T R
出版信息
Antimicrob Agents Chemother. 1982 Jul;22(1):176-9. doi: 10.1128/AAC.22.1.176.
Abstract
Methyl daunosamine inhibited the replication of herpes simplex virus type 1 in a dose-dependent manner. The growth of the host Vero cells was not affected by daunosamine levels that had significant antiviral activity (2.5 mM) but was inhibited by concentrations of 5 mM or greater. Methyl daunosamine appears to be unique among the sugars with antiviral activity because at antiviral concentrations it did not inhibit the glycosylation of macromolecules.
摘要
甲基柔红糖胺以剂量依赖的方式抑制单纯疱疹病毒1型的复制。具有显著抗病毒活性（2.5 mM）的柔红糖胺水平不会影响宿主Vero细胞的生长，但5 mM或更高的浓度会抑制其生长。甲基柔红糖胺在具有抗病毒活性的糖类中似乎是独特的，因为在抗病毒浓度下它不会抑制大分子的糖基化。
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