2-脱氧-D-葡萄糖对非洲绿猴肾细胞生长及单纯疱疹病毒复制抑制作用的解离
Dissociation of the inhibitory effects of 2-deoxy-D-glucose on Vero cell growth and the replication of herpes simplex virus.
作者信息
Spivack J G, Prusoff W H, Tritton T R
出版信息
Antimicrob Agents Chemother. 1982 Aug;22(2):284-8. doi: 10.1128/AAC.22.2.284.
Abstract
Vero cells treated for 24 h with a concentration of 2-deoxy-D-glucose (2dGlc) that inhibited the production of infectious herpes simplex virus type 1 grew at the same rate as untreated cells. Longer exposures to 2dGlc inhibited the growth of Vero cells in a dose-dependent manner, but without any loss of viability, and could be reversed by replating the cells in the absence of drug. To exhibit antiviral activity, 2dGlc had to be present during the replication cycle of herpes simplex virus type 1. Treatment of Vero cells, even with a cytotoxic dose of 2dGlc, was without effect on the yield of infectious virus, provided the drug was removed before infection. Thus the antiviral effects of 2dGlc were not the result of, and appeared to be independent of, persistent host cell toxicity.
摘要
用抑制单纯疱疹病毒1型感染性病毒产生的浓度的2-脱氧-D-葡萄糖（2dGlc）处理24小时的Vero细胞，其生长速度与未处理的细胞相同。长时间暴露于2dGlc会以剂量依赖的方式抑制Vero细胞的生长，但不会导致任何活力丧失，并且通过在无药物的情况下重新接种细胞可以逆转这种抑制作用。为了表现出抗病毒活性，2dGlc必须在单纯疱疹病毒1型的复制周期中存在。即使使用细胞毒性剂量的2dGlc处理Vero细胞，如果在感染前去除药物，对感染性病毒的产量也没有影响。因此，2dGlc的抗病毒作用不是持续性宿主细胞毒性的结果，并且似乎与之无关。
相似文献
1
Dissociation of the inhibitory effects of 2-deoxy-D-glucose on Vero cell growth and the replication of herpes simplex virus.2-脱氧-D-葡萄糖对非洲绿猴肾细胞生长及单纯疱疹病毒复制抑制作用的解离
Antimicrob Agents Chemother. 1982 Aug;22(2):284-8. doi: 10.1128/AAC.22.2.284.
2
A study of the antiviral mechanism of action of 2-deoxy-D-glucose: normally glycosylated proteins are not strictly required for herpes simplex virus attachment but increase viral penetration and infectivity.
Virology. 1982 Nov;123(1):123-38. doi: 10.1016/0042-6822(82)90300-2.
3
In vitro effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5'-amino-5-iodo-2',5'-dideoxyuridine and 2-deoxy-D-glucose on latent ganglionic herpes simplex virus infection.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷、5'-氨基-5-碘-2'，5'-二脱氧尿苷和2-脱氧-D-葡萄糖对潜伏性神经节单纯疱疹病毒感染的体外作用。
Antiviral Res. 1984 Apr;4(1-2):53-61. doi: 10.1016/0166-3542(84)90025-1.
4
Unusual membranous structures found in cells infected with herpes simplex virus type 2 maintained in media containing 2-deoxy-D-glucose.在含有2-脱氧-D-葡萄糖的培养基中培养的感染了2型单纯疱疹病毒的细胞中发现的异常膜结构。
Microbiol Immunol. 1978;22(9):575-9. doi: 10.1111/j.1348-0421.1978.tb00406.x.
5
Inhibition of herpes simplex virus replication by methyl daunosamine.甲基柔红糖胺对单纯疱疹病毒复制的抑制作用
Antimicrob Agents Chemother. 1982 Jul;22(1):176-9. doi: 10.1128/AAC.22.1.176.
6
Effects of 2-deoxy-D-glucose and 3 deazauridine individually and in combination on the replication of Japanese B encephalitis virus.2-脱氧-D-葡萄糖和3-脱氮尿苷单独及联合使用对日本乙型脑炎病毒复制的影响。
Antimicrob Agents Chemother. 1977 Mar;11(3):475-81. doi: 10.1128/AAC.11.3.475.
7
Adsorption and penetration of enveloped herpes simplex virus particles modified by tunicamycin or 2-deoxy-D-glucose.
J Gen Virol. 1982 Dec;63(2):343-9. doi: 10.1099/0022-1317-63-2-343.
8
9
2-deoxy-D-glucose inhibition of herpes simplex virus type-1 receptor expression.
Antiviral Res. 1986 May;6(3):137-49. doi: 10.1016/0166-3542(86)90008-2.
10
Inhibition of vesicular stomatitis virus multiplication in Vero cells by 2-deoxy-D-glucose.2-脱氧-D-葡萄糖对水泡性口炎病毒在非洲绿猴肾细胞中增殖的抑制作用
Acta Virol. 1979 May;23(3):210-20.
引用本文的文献
1
Carnosic Acid Inhibits Herpes Simplex Virus Replication by Suppressing Cellular ATP Synthesis.迷迭香酸通过抑制细胞 ATP 合成抑制单纯疱疹病毒复制。
Int J Mol Sci. 2024 May 3;25(9):4983. doi: 10.3390/ijms25094983.
2
Novobiocin and coumermycin A1 inhibit viral replication and the reactivation of herpes simplex virus type 1 from the trigeminal ganglia of latently infected mice.新生霉素和香豆霉素A1可抑制病毒复制以及潜伏感染小鼠三叉神经节中单纯疱疹病毒1型的再激活。
J Virol. 1987 Oct;61(10):3288-91. doi: 10.1128/JVI.61.10.3288-3291.1987.
3
Expression of herpes simplex virus type 1 (HSV-1) latency-associated transcripts and transcripts affected by the deletion in avirulent mutant HFEM: evidence for a new class of HSV-1 genes.1型单纯疱疹病毒（HSV-1）潜伏相关转录本及无毒突变体HFEM中受缺失影响的转录本的表达：一类新的HSV-1基因的证据
J Virol. 1988 Sep;62(9):3281-7. doi: 10.1128/JVI.62.9.3281-3287.1988.
4
Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection.单纯疱疹病毒1型潜伏相关转录本在小鼠急性感染及潜伏感染再激活期间三叉神经节中的表达
J Virol. 1988 May;62(5):1479-85. doi: 10.1128/JVI.62.5.1479-1485.1988.
5
Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome.小鼠外周和中枢神经系统组织中的潜伏性单纯疱疹病毒1型转录本定位于病毒基因组的相似区域。
J Virol. 1988 Mar;62(3):749-56. doi: 10.1128/JVI.62.3.749-756.1988.
6
Detection of herpes simplex virus type 1 transcripts during latent infection in mice.小鼠潜伏感染期间单纯疱疹病毒1型转录本的检测
J Virol. 1987 Dec;61(12):3841-7. doi: 10.1128/JVI.61.12.3841-3847.1987.
本文引用的文献
1
The effects of 2-deoxyglucose on the growth and metabolism of cultured human cells.2-脱氧葡萄糖对培养的人类细胞生长和代谢的影响。
J Biol Chem. 1961 Jul;236:1887-90.
2
Inhibition of influenza virus multiplication with a glucose antimetabolite (2-deoxy-D-glucose).用葡萄糖抗代谢物（2-脱氧-D-葡萄糖）抑制流感病毒增殖。
Nature. 1959 Jan 24;183(4656):271-2. doi: 10.1038/183271b0.
3
4
Effect of 2-deoxy-D-glucose on the multiplication of Semliki Forest virus and the reversal of the block by mannose.2-脱氧-D-葡萄糖对塞姆利基森林病毒增殖的影响以及甘露糖对该阻断作用的逆转
Virology. 1973 Jul;54(1):179-89. doi: 10.1016/0042-6822(73)90127-x.
5
Inhibition of influenza viral glycoprotein synthesis by sugars.糖类对流感病毒糖蛋白合成的抑制作用。
Microbios. 1972 Jan;5(17):41-50.
6
Inhibition of the multiplication of vesicular stomatitis and Newcastle disease virus by 2-deoxy-d-glucose.2-脱氧-D-葡萄糖对水疱性口炎病毒和新城疫病毒增殖的抑制作用
J Virol. 1974 Jun;13(6):1186-93. doi: 10.1128/JVI.13.6.1186-1193.1974.
7
Effects of 2-deoxy-D-glucose on herpes simplex virus replication.2-脱氧-D-葡萄糖对单纯疱疹病毒复制的影响。
Virology. 1973 Apr;52(2):447-55. doi: 10.1016/0042-6822(73)90340-1.
8
Inhibition of the multiplication of enveloped RNA-viruses by glucosamine and 2-deoxy-D-glucose.氨基葡萄糖和2-脱氧-D-葡萄糖对包膜RNA病毒增殖的抑制作用。
J Gen Virol. 1972 Mar;14(3):251-9. doi: 10.1099/0022-1317-14-3-251.
9
The effects of low concentrations of 2-deoxy-D-glucose on the growth, surface architecture, and glycoprotein metabolism of P388 lymphoma cells.
Biochem Biophys Res Commun. 1975 Mar 3;63(1):164-71. doi: 10.1016/s0006-291x(75)80025-8.
10
Properties of a baby-hamster-kidney cell line with increased resistance of 2-deoxy-D-glucose.
Eur J Biochem. 1977 Jan;72(2):275-81. doi: 10.1111/j.1432-1033.1977.tb11250.x.
Zotero 插件