Balutsov M, Kemileva Z
Eksp Med Morfol. 1979;18(1):17-21.
The authors followed in dynamics the systolic arterial blood pressure and morphometric changes in the myocardium (cardiac, index, mean number of myocardial cells per unit of area c I mm2, mean diameter of the myocardial cells of the papillary muscles and subendocardial laer of the left ventricle) in thymectomized and sham thymectomized rats. The studies were made after thymectomy and sham thymectomy on the second, sixth, twelfth and sixteenth week. The systolic arterial blood pressure in thymectomized rats was elevated gradually and reached up to 170 mmHg on the sixteenth week, but it was in normal ranges in sham thymectomized animals. The cardiac index and mean diameter of the myocardial cells were larger in thymectomized rats, but the mean number of cells was smaller in comparison with sham thymectomized animals-results showing development of myocardial hyperthrophy after thymectomy. The induced myocardial changes were probably of adaptive character and could be due to neurohormonal mechanisms and hemodynamic loading of the heart becuase of the elevated arterial blood pressure after thymectomy.
作者跟踪观察了胸腺切除大鼠和假胸腺切除大鼠的动脉收缩压动态变化以及心肌的形态学改变（心脏指数、每平方毫米心肌细胞的平均数量、乳头肌和左心室心内膜下层心肌细胞的平均直径）。研究在胸腺切除和假胸腺切除后的第2周、第6周、第12周和第16周进行。胸腺切除大鼠的动脉收缩压逐渐升高，在第16周时达到170 mmHg，但假胸腺切除动物的动脉收缩压处于正常范围。与假胸腺切除动物相比，胸腺切除大鼠的心脏指数和心肌细胞平均直径更大，但细胞平均数量更少，结果显示胸腺切除后出现心肌肥大。诱导的心肌变化可能具有适应性特征，可能是由于神经激素机制以及胸腺切除后动脉血压升高导致的心脏血流动力学负荷增加所致。
