多瘤病毒 - 抗体复合物的形成及其生物学作用。补体的关键作用。
Formation and biologic role of polyoma virus-antibody complexes. A critical role for complement.
作者信息
Oldstone M B, Cooper N R, Larson D L
出版信息
J Exp Med. 1974 Aug 1;140(2):549-65. doi: 10.1084/jem.140.2.549.
Abstract
Interaction of polyoma virus, specific antibody, and complement has been studied. Firm evidence has been gathered that C1 through C3 and not C5 through C9 enhance neutralization of virus-antiviral antibody (V-Ab) complexes. C enhancement of neutralization occurs primarily by agglutination of V-Ab complexes and not by virion lysis or attachment of large protein molecules to the V-Ab complex. In this model, binding of C1, 4, 2, 3 to the V-Ab complex may explain why some viruses concentrate in or infect certain cells bearing C3 receptors such as B lymphocytes, macrophages, and monocytes.
摘要
已对多瘤病毒、特异性抗体和补体之间的相互作用进行了研究。已收集到确凿证据表明，C1至C3而非C5至C9可增强病毒 - 抗病毒抗体（V - Ab）复合物的中和作用。补体增强中和作用主要是通过V - Ab复合物的凝集，而非病毒粒子裂解或大蛋白质分子附着于V - Ab复合物。在该模型中，C1、4、2、3与V - Ab复合物的结合可能解释了为何某些病毒会在带有C3受体的特定细胞（如B淋巴细胞、巨噬细胞和单核细胞）中聚集或感染。
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本文引用的文献
1
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J Exp Med. 1965 Aug 1;122(2):277-98. doi: 10.1084/jem.122.2.277.
2
MOLECULAR MECHANISM OF FORMATION OF AN ANTIGEN-ANTIBODY COMPLEX.抗原-抗体复合物形成的分子机制
Nature. 1965 Jan 9;205:147-9. doi: 10.1038/205147a0.
3
ISOLATION AND DESCRIPTION OF THE FOURTH COMPONENT OF HUMAN COMPLEMENT.人补体第四成分的分离与描述
J Exp Med. 1963 Sep 1;118(3):447-66. doi: 10.1084/jem.118.3.447.
4
Infectious virus-antibody complex in the blood of chronically infected mice.慢性感染小鼠血液中的传染性病毒-抗体复合物。
J Exp Med. 1966 Jul 1;124(1):81-97. doi: 10.1084/jem.124.1.81.
5
The morphological and biological effects of various antisera on avian infectious bronchitis virus.各种抗血清对禽传染性支气管炎病毒的形态学和生物学效应。
J Gen Virol. 1968 Jul;3(1):97-102. doi: 10.1099/0022-1317-3-1-97.
6
Production of ultrastructural membrane lesions by the fifth component of complement.补体第五成分产生超微结构的膜损伤。
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7
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8
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