无嗜异性抗体的传染性单核细胞增多症中针对爱泼斯坦-巴尔病毒的IgM抗体
IgM antibodies specific for Epstein-Barr virus in infectious mononucleosis without heterophil antibodies.
作者信息
Nikoskelainen J, Leikola J, Klemola E
出版信息
Br Med J. 1974 Oct 12;4(5936):72-5. doi: 10.1136/bmj.4.5936.72.
Abstract
IgM antibodies specific for Epstein-Barr (E.B.) virus were demonstrable in all but one out of 46 patients diagnosed as having infectious mononucleosis wihout heterophil antibodies; cytomegalovirus aetiology was excluded. In all but two cases the highest titre was found in the first sample. In 21 patients a significant decrease was seen within a few weeks. IgG antibodies to E.B. virus, mostly remaining at a constant level, were demonstrable in all cases. IgM antibodies to E.B. virus were found in only five out of 300 controls.The results suggest that in a disease similar to infectious mononucleosis without heterophil antibodies testing of transient E.B. virus-specific IgM antibodies makes a rapid aetiological diagnosis possible and that in clinically well-defined cases viruses other than E.B. virus and cytomegalovirus are unlikely to be causal agents.
摘要
在46例被诊断为无嗜异性抗体的传染性单核细胞增多症患者中，除1例之外，其余患者均可检测到针对EB病毒的IgM抗体；已排除巨细胞病毒病因。除2例之外，其余所有病例在首个样本中检测到的滴度最高。21例患者在几周内出现显著下降。所有病例均可检测到针对EB病毒的IgG抗体，其大多保持在恒定水平。在300名对照者中，仅5人检测到针对EB病毒的IgM抗体。结果表明，在与无嗜异性抗体的传染性单核细胞增多症相似的疾病中，检测短暂存在的EB病毒特异性IgM抗体可实现快速病因诊断，并且在临床明确诊断的病例中，除EB病毒和巨细胞病毒之外的其他病毒不太可能是致病因子。
相似文献
1
IgM antibodies specific for Epstein-Barr virus in infectious mononucleosis without heterophil antibodies.无嗜异性抗体的传染性单核细胞增多症中针对爱泼斯坦-巴尔病毒的IgM抗体
Br Med J. 1974 Oct 12;4(5936):72-5. doi: 10.1136/bmj.4.5936.72.
2
3
Antibody response to Epstein-Barr virus in infectious mononucleosis.传染性单核细胞增多症中针对爱泼斯坦-巴尔病毒的抗体反应。
Infect Immun. 1975 Jan;11(1):42-51. doi: 10.1128/iai.11.1.42-51.1975.
4
Limitations of immunofluorescence tests in the diagnosis of infectious mononucleosis.免疫荧光试验在传染性单核细胞增多症诊断中的局限性。
Can Med Assoc J. 1974 Apr 6;110(7):793-4 passim.
5
Infectious mononucleosis and mononucleosis-like illnesses in children and adults in Saudi Arabia.沙特阿拉伯儿童和成人的传染性单核细胞增多症及类单核细胞增多症疾病
J Trop Pediatr. 1989 Jun;35(3):121-5. doi: 10.1093/tropej/35.3.121.
6
Measurement of heterophil antibody and antibodies to EB viral capsid antigen IgG and IgM in suspected cases of infectious mononucleosis.在疑似传染性单核细胞增多症病例中检测嗜异性抗体以及针对EB病毒衣壳抗原的IgG和IgM抗体。
J Clin Pathol. 1976 Sep;29(9):841-7. doi: 10.1136/jcp.29.9.841.
7
A prospective evaluation of heterophile and Epstein-Barr virus-specific IgM antibody tests in clinical and subclinical infectious mononucleosis: Specificity and sensitivity of the tests and persistence of antibody.嗜异性及EB病毒特异性IgM抗体检测在临床及亚临床传染性单核细胞增多症中的前瞻性评估：检测的特异性、敏感性及抗体持续性
J Infect Dis. 1975 Nov;132(5):546-54. doi: 10.1093/infdis/132.5.546.
8
Epstein-Barr virus and heterophile antibodies in infectious mononucleosis.传染性单核细胞增多症中的爱泼斯坦-巴尔病毒和嗜异性抗体。
Isr J Med Sci. 1974 Jul;10(7):731-7.
9
Epstein-Barr virus and cytomegalovirus antibodies in infectious mononucleosis.传染性单核细胞增多症中的爱泼斯坦-巴尔病毒和巨细胞病毒抗体
Acta Microbiol Acad Sci Hung. 1977;24(1):13-9.
10
Infectious-mononucleosis-like disease with negative heterophil agglutination test. Clinical features in relation to Epstein-Barr virus and cytomegalovirus antibodies.嗜异性凝集试验阴性的传染性单核细胞增多症样疾病。与爱泼斯坦-巴尔病毒和巨细胞病毒抗体相关的临床特征。
J Infect Dis. 1970 Jun;121(6):608-14. doi: 10.1093/infdis/121.6.608.
引用本文的文献
1
Evaluation of the Serological Point-of-Care Testing of Infectious Mononucleosis by Data of External Quality Control Samples.利用外部质量控制样本数据评估传染性单核细胞增多症的血清即时检测
Microbiol Insights. 2020 Dec 3;13:1178636120977481. doi: 10.1177/1178636120977481. eCollection 2020.
2
Application of a commercial immunoblot to define EBV IgG seroprofiles.应用商业免疫印迹法确定EBV IgG血清学特征。
J Clin Lab Anal. 2015 Jan;29(1):47-51. doi: 10.1002/jcla.21726. Epub 2014 Mar 28.
3
Evaluation of four commercial systems for the diagnosis of Epstein-Barr virus primary infections.四种用于诊断爱泼斯坦-巴尔病毒原发性感染的商业系统的评估
Clin Vaccine Immunol. 2011 Mar;18(3):444-8. doi: 10.1128/CVI.00486-10. Epub 2010 Dec 29.
4
Rapid detection of infectious mononucleosis-associated heterophile antibodies by a novel immunochromatographic assay and a latex agglutination test.通过新型免疫层析法和乳胶凝集试验快速检测传染性单核细胞增多症相关嗜异性抗体。
J Clin Microbiol. 1993 Jun;31(6):1597-600. doi: 10.1128/jcm.31.6.1597-1600.1993.
5
Comparison of nonspecific reactivity in indirect and reverse immunoassays for measles and mumps immunoglobulin M antibodies.麻疹和腮腺炎免疫球蛋白M抗体间接和反向免疫测定中非特异性反应性的比较。
J Clin Microbiol. 1984 Nov;20(5):972-6. doi: 10.1128/jcm.20.5.972-976.1984.
6
Detection of IgM antibodies to measles virus by enzyme-immunoassay.采用酶免疫测定法检测麻疹病毒IgM抗体。
Med Microbiol Immunol. 1983;171(4):187-98. doi: 10.1007/BF02123492.
7
Detection of immunoglobulin M antibody to Epstein-Barr virus by use of an enzyme-labeled antigen.利用酶标记抗原检测抗爱泼斯坦-巴尔病毒免疫球蛋白M抗体。
J Clin Microbiol. 1982 Aug;16(2):361-6. doi: 10.1128/jcm.16.2.361-366.1982.
8
A prospective study on infectious mononucleosis in childhood--symptoms, serology, Epstein-Barr-Virus specific leukocyte migration inhibition.儿童传染性单核细胞增多症的前瞻性研究——症状、血清学、爱泼斯坦-巴尔病毒特异性白细胞游走抑制
Infection. 1982;10(3):139-43. doi: 10.1007/BF01640763.
9
Primary Epstein-Barr virus infection in early childhood.幼儿期原发性爱泼斯坦-巴尔病毒感染。
Arch Dis Child. 1981 Jan;56(1):49-52. doi: 10.1136/adc.56.1.49.
10
Encephalitis and cerebellar ataxia associated with Epstein-Barr virus infections.与爱泼斯坦-巴尔病毒感染相关的脑炎和小脑共济失调。
Ulster Med J. 1980;49(2):158-64.
本文引用的文献
1
SEROLOGIC DIAGNOSIS OF INFECTIOUS MONONUCLEOSIS. A COMPARATIVE STUDY OF FIVE TESTS.传染性单核细胞增多症的血清学诊断。五种检测方法的比较研究。
Am J Clin Pathol. 1964 Feb;41:115-25. doi: 10.1093/ajcp/41.2.115.
2
Infectious mononucleosis in University of Wisconsin students. Report of a five-year investigation.威斯康星大学学生中的传染性单核细胞增多症。一项五年调查的报告。
Am J Hyg. 1960 May;71:342-62. doi: 10.1093/oxfordjournals.aje.a120118.
3
Horse agglutinins in infectious mononueleosis. 3. riterion for differential diagnosis.传染性单核细胞增多症中的马凝集素。3. 鉴别诊断标准。
J Clin Pathol. 1968 Sep;21(5):631-4. doi: 10.1136/jcp.21.5.631.
4
Fluorescent staining and human IgM.荧光染色与人类免疫球蛋白M
Br Med J. 1971 Sep 18;3(5776):707. doi: 10.1136/bmj.3.5776.707.
5
Seroepidemiologic studies of infectious mononucleosis with EB virus.关于EB病毒所致传染性单核细胞增多症的血清流行病学研究。
N Engl J Med. 1968 Nov 21;279(21):1121-7. doi: 10.1056/NEJM196811212792101.
6
Infectious mononucleosis. Clinical manifestations in relation to EB virus antibodies.传染性单核细胞增多症。与EB病毒抗体相关的临床表现。
JAMA. 1968 Jan 15;203(3):205-9. doi: 10.1001/jama.203.3.205.
7
Secondary fluorescent staining of virus antigens by rheumatoid factor and fluorescein-conjugated anti-IgM.类风湿因子和荧光素标记的抗IgM对病毒抗原进行二次荧光染色。
Ann Rheum Dis. 1973 Jan;32(1):53-7. doi: 10.1136/ard.32.1.53.
8
Cytomegalovirus infection in previously healthy adults.既往健康成年人的巨细胞病毒感染
Ann Intern Med. 1973 Aug;79(2):267-8. doi: 10.7326/0003-4819-79-2-267.
9
Epstein-Barr virus and infectious mononucleosis.爱泼斯坦-巴尔病毒与传染性单核细胞增多症
N Engl J Med. 1973 Feb 1;288(5):263-4. doi: 10.1056/NEJM197302012880512.
10
IgM antibodies to Epstein-Barr virus in infectious mononucleosis.传染性单核细胞增多症中针对EB病毒的IgM抗体。
Arch Gesamte Virusforsch. 1972;37(4):332-9. doi: 10.1007/BF01241456.
Zotero 插件