Nikoskelainen J, Leikola J, Klemola E
Br Med J. 1974 Oct 12;4(5936):72-5. doi: 10.1136/bmj.4.5936.72.
IgM antibodies specific for Epstein-Barr (E.B.) virus were demonstrable in all but one out of 46 patients diagnosed as having infectious mononucleosis wihout heterophil antibodies; cytomegalovirus aetiology was excluded. In all but two cases the highest titre was found in the first sample. In 21 patients a significant decrease was seen within a few weeks. IgG antibodies to E.B. virus, mostly remaining at a constant level, were demonstrable in all cases. IgM antibodies to E.B. virus were found in only five out of 300 controls.The results suggest that in a disease similar to infectious mononucleosis without heterophil antibodies testing of transient E.B. virus-specific IgM antibodies makes a rapid aetiological diagnosis possible and that in clinically well-defined cases viruses other than E.B. virus and cytomegalovirus are unlikely to be causal agents.
在46例被诊断为无嗜异性抗体的传染性单核细胞增多症患者中，除1例之外，其余患者均可检测到针对EB病毒的IgM抗体；已排除巨细胞病毒病因。除2例之外，其余所有病例在首个样本中检测到的滴度最高。21例患者在几周内出现显著下降。所有病例均可检测到针对EB病毒的IgG抗体，其大多保持在恒定水平。在300名对照者中，仅5人检测到针对EB病毒的IgM抗体。结果表明，在与无嗜异性抗体的传染性单核细胞增多症相似的疾病中，检测短暂存在的EB病毒特异性IgM抗体可实现快速病因诊断，并且在临床明确诊断的病例中，除EB病毒和巨细胞病毒之外的其他病毒不太可能是致病因子。
