Powell H R, Rotenberg E, Williams A L, McCredie D A
Arch Dis Child. 1974 Oct;49(10):802-7. doi: 10.1136/adc.49.10.802.
Plasma renin activity (PRA) was determined in 10 children with acute glomerulonephritis and in 10 with the haemolytic-uraemic syndrome (HUS). Low renin levels were found in the hypertensive children with acute nephritis, all of whom had evidence of fluid overload. The amount of this overload correlated directly with the degree of hypertension and inversely with PRA. All the hypertensive children with HUS had high levels of plasma renin, and the highest levels were found in those cases who were subsequently shown to have the more severe degree of renal arteriolar occlusion. The findings emphasize the importance of measures designed to reduce salt and water overloading in the management of hypertension in acute nephritis, while drugs which suppress plasma renin are more likely to control blood pressure in HUS. Estimation of PRA may provide a guide to the management of hypertension in acute renal insufficiency.
对10名急性肾小球肾炎患儿和10名溶血尿毒综合征（HUS）患儿测定了血浆肾素活性（PRA）。在患有急性肾炎的高血压患儿中发现肾素水平较低，所有这些患儿均有液体超负荷的证据。这种超负荷的量与高血压程度直接相关，与PRA呈负相关。所有患有HUS的高血压患儿血浆肾素水平都很高，在那些随后被证明肾小动脉闭塞程度更严重的病例中发现了最高水平。这些发现强调了在急性肾炎高血压管理中采取措施减少盐和水超负荷的重要性，而抑制血浆肾素的药物更有可能控制HUS中的血压。PRA的测定可为急性肾功能不全高血压的管理提供指导。
