前列腺素可恢复东莨菪碱引起的豚鼠回肠抑制作用。
Prostaglandins restore the hyoscine-induced inhibition of the guinea-pig ileum.
作者信息
Laekeman G M, Herman A G
出版信息
Prostaglandins. 1978 May;15(5):829-37. doi: 10.1016/0090-6980(78)90149-1.
PMID:704907
Abstract
Prostaglandins E1, E2 and F2alpha as well as arachidonic acid partially increase the hyoscine inhibited twitch and tetanic responses of the guinea-pig ileum to electrical stimulation. They also produce a shift to the left of the dose-effect curve for acetylcholine and histamine previously displaced to the right by the administration of hyoscine or mepyramine. These results indicate a postsynaptic sensitization effect of the prostaglandins rather than a presynaptic facilitatory activity.
摘要
前列腺素E1、E2和F2α以及花生四烯酸可部分增强东莨菪碱对豚鼠回肠电刺激所致的抽搐和强直反应的抑制作用。它们还可使乙酰胆碱和组胺的剂量效应曲线向左移动，而这两种物质的剂量效应曲线在给予东莨菪碱或美吡拉敏后已向右移位。这些结果表明，前列腺素具有突触后致敏作用，而非突触前易化活性。
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