5'-三磷酸腺苷对豚鼠回肠的直接和间接作用
Direct and indirect effects of adenosine 5'-triphosphate on guinea-pig ileum.
作者信息
Watt A J
出版信息
Br J Pharmacol. 1982 Dec;77(4):725-30. doi: 10.1111/j.1476-5381.1982.tb09352.x.
Abstract
1 The inhibitory effects of adenosine 5'-triphosphate (ATP) were compared on the responses to electrical stimulation, and to direct and indirect stimulation by drugs of the longitudinal smooth muscle of guinea-pig ileum before and after blocking nervous activity. 2 While the major inhibitory effect of ATP was an indirect one on the intramural excitatory nerves, there was also a small direct effect on the muscle. 3 ATP also had direct and indirect excitatory effects. The direct effect particularly was only seen with high concentrations of ATP, but the appearance of these excitatory effects may be affected by the inhibitory actions.
摘要
- 比较了5'-三磷酸腺苷（ATP）对豚鼠回肠纵行平滑肌在阻断神经活动前后对电刺激、药物直接刺激和间接刺激反应的抑制作用。2. 虽然ATP的主要抑制作用是对壁内兴奋性神经的间接作用，但对肌肉也有轻微的直接作用。3. ATP也有直接和间接的兴奋作用。特别是直接作用仅在高浓度ATP时才可见，但这些兴奋作用的出现可能受抑制作用的影响。
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引用本文的文献
本文引用的文献
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INHIBITION OF INTESTINAL SMOOTH MUSCLE.肠平滑肌的抑制
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On the action of prostaglandin E1 and prostaglandins from brain on the isolated rat stomach.前列腺素E1及脑源性前列腺素对离体大鼠胃的作用
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