α-鹅膏蕈碱对前列腺类固醇-蛋白质受体复合物刺激前列腺核糖核酸聚合酶的影响。
Effects of alpha-amanitin on the stimulation of prostatic ribonucleic acid polymerase by prostatic steroid-protein receptor complexes.
作者信息
Davies P, Griffiths K
出版信息
Biochem J. 1974 Jun;140(3):565-7. doi: 10.1042/bj1400565.
Abstract
Stimulation of prostatic RNA polymerase in vitro by prostatic 17beta-hydroxy-5alpha-androstan-3-one (5alpha-dihydrotestosterone)-receptor complexes has been previously reported. By use of the selective inhibitor, alpha-amanitin, we have shown that both nucleolar and extranucleolar RNA polymerase activities may be stimulated, but stimulation is abolished at high ionic strength.
摘要
先前已有报道，前列腺17β-羟基-5α-雄甾烷-3-酮（5α-双氢睾酮）-受体复合物在体外可刺激前列腺RNA聚合酶。通过使用选择性抑制剂α-鹅膏蕈碱，我们已经表明核仁及核仁外的RNA聚合酶活性均可被刺激，但在高离子强度下刺激作用会消失。
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