Ho K J
Int J Chronobiol. 1979;6(1):39-50.
Sixty three hamsters were divided into two groups which were exposed to the same rigid lighting schedule (06(00)--18(00)) but fed at different time intervals (18(00)--22(00), and 08(00)--12(00), respectively) for five weeks. The cholesterol synthetic activity was then determined in liver, gastrointestinal tract, and kidney by in vivo incorporation of (1--14C)-acetate into cholesterol at different hours of the day. A remarkable circadian rhythm of the activity was found in the liver and small intestine, but not in other organs. Regardless of the lighting schedule, the nadir occurred, in both groups, always at the end of the fasting period and the peak four to six hours after feeding. The study clearly indicated the major role of diet in regulation of such phenomenon.
63只仓鼠被分为两组，两组都暴露于相同的严格光照时间表（06:00 - 18:00），但分别在不同的时间间隔（分别为18:00 - 22:00和08:00 - 12:00）喂食五周。然后通过在一天中的不同时间将（1 - 14C） - 乙酸盐体内掺入胆固醇来测定肝脏、胃肠道和肾脏中的胆固醇合成活性。在肝脏和小肠中发现了该活性的显著昼夜节律，但在其他器官中未发现。无论光照时间表如何，两组的最低点总是出现在禁食期结束时，而峰值出现在喂食后四到六小时。该研究清楚地表明了饮食在调节这种现象中的主要作用。
