Hussain M Mahmood, Pan Xiaoyue
Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA.
Trends Endocrinol Metab. 2009 May;20(4):177-85. doi: 10.1016/j.tem.2009.01.001. Epub 2009 Apr 6.
Light and food are two major environmental factors that impact daily life. Light entrainment is centrally controlled by suprachiasmatic nuclei of the hypothalamus. Food entrainment might require cooperation between the intestine and dorsomedial hypothalamus. Clock genes that are essential for light entrainment also play a part in food entrainment. Understanding the role of clock genes in the entrainment of intestinal functions, as well as in gut-brain communication during food entrainment, will enhance our understanding of gastrointestinal and metabolic disorders. This review highlights recent studies examining light- and food-entrained regulation of plasma lipids and of various intestinal activities and offers insight into the role of the intestine in food entrainment.
光和食物是影响日常生活的两个主要环境因素。光诱导由下丘脑的视交叉上核进行中枢控制。食物诱导可能需要肠道与下丘脑背内侧核之间的协作。对光诱导至关重要的生物钟基因在食物诱导中也发挥作用。了解生物钟基因在肠道功能诱导以及食物诱导过程中肠-脑通讯中的作用，将增进我们对胃肠道和代谢紊乱的理解。本综述重点介绍了近期关于光和食物诱导对血浆脂质及各种肠道活动调节的研究，并深入探讨了肠道在食物诱导中的作用。
