Graham M Y, Weisblum B
J Bacteriol. 1979 Mar;137(3):1464-7. doi: 10.1128/jb.137.3.1464-1467.1979.
Coresistance to macrolide, lincosamide, and streptogramin B-type (MLS) antibiotics by a common biochemical mechanism characterizes clinically resistant pathogens. Of 10 streptomycetes tested for resistance to macrolide, lincosamide, and streptogramin B-type antibiotics, only 1, Streptomyces erythreus, the organism used for production of erythromycin, was found resistant to all three classes; moreover, it was the only streptomycete in the series tested found to contain N6-dimethyladenine (m62A) in 23S ribosomal ribonucleic acid, the structural alteration of ribosomal ribonucleic acid associated with clinical resistance. Of the seven streptomycetes tested for the presence of m62A and N6-methyladenine (m6A), two, S. fradiae and S. cirratus, which produce the macrolide antibiotics tylosin and cirramycin, respectively, were found to contain m6A, but not m62A. The remaining strains tested, including strains which produce lincomycin and streptogramins, contained neither m6A nor m62A.
临床上耐药病原体的一个共同生化机制是对大环内酯类、林可酰胺类和链阳菌素B型（MLS）抗生素产生共同耐药性。在测试的10种对大环内酯类、林可酰胺类和链阳菌素B型抗生素耐药的链霉菌中，只有一种，即用于生产红霉素的红色链霉菌，对所有这三类抗生素都有耐药性；此外，它是该系列测试中唯一被发现23S核糖体核糖核酸中含有N6-二甲基腺嘌呤（m62A）的链霉菌，核糖体核糖核酸的这种结构改变与临床耐药性有关。在测试m62A和N6-甲基腺嘌呤（m6A）存在情况的7种链霉菌中，分别产生大环内酯类抗生素泰乐菌素和环拉霉素的两种，即弗氏链霉菌和卷曲链霉菌，被发现含有m6A，但不含有m62A。其余测试菌株，包括产生林可霉素和链阳菌素的菌株，既不含有m6A也不含有m62A。
