β-肾上腺素能阻断剂对豚鼠气道溢流制备中支气管收缩药物反应的影响。描述气道溢流法新改良的附录。
Effect of beta-adrenoceptive blocking agents on the response to bronchoconstrictor drugs in the guinea-pig air overflow preparation. Appendix describing a new modification of the air overflow method.
作者信息
Burden D T, Parkes M W, Gardiner D G
出版信息
Br J Pharmacol. 1971 Jan;41(1):122-31. doi: 10.1111/j.1476-5381.1971.tb09942.x.
Abstract
- Propranolol augmented the bronchoconstrictor response to methacholine or histamine, recorded by air overflow in the anaesthetized, vagotomized guinea-pig.2. After adrenalectomy, propranolol was still active, though less so than before.3. In the pithed guinea-pig, there was no augmentation of the effect of bronchoconstrictors on air overflow. The action of propranolol could thus be due to the beta-adrenoceptor blockade of compensatory sympathetic bronchodilator activity, as concluded by McCulloch, Proctor & Rand (1967).4. Electrical stimulation of the thoracic region of the spinal cord of the pithed guinea-pig reduced the effect of bronchoconstrictors on air overflow. This reduction could be blocked by propranolol; practolol was much less effective.
摘要
在麻醉、迷走神经切断的豚鼠中，通过空气溢出记录发现，普萘洛尔增强了对乙酰甲胆碱或组胺的支气管收缩反应。
肾上腺切除术后，普萘洛尔仍有活性，尽管比之前活性降低。
在脊髓损毁的豚鼠中，支气管收缩剂对空气溢出的作用未增强。因此，如麦卡洛赫、普罗克特和兰德（1967年）所总结的，普萘洛尔的作用可能是由于对代偿性交感神经支气管扩张活性的β-肾上腺素能受体阻滞。
对脊髓损毁的豚鼠脊髓胸段进行电刺激可降低支气管收缩剂对空气溢出的作用。这种降低可被普萘洛尔阻断；心得宁的效果则差得多。
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本文引用的文献
1
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Br J Pharmacol Chemother. 1965 Apr;24(2):332-8. doi: 10.1111/j.1476-5381.1965.tb01719.x.
2
EFFECT OF A BETA-ADRENERGIC-BLOCKING AGENT, PROPRANOLOL, ON ASTHMATICS.β-肾上腺素能阻滞剂普萘洛尔对哮喘患者的影响。
Lancet. 1964 Nov 21;2(7369):1101-2. doi: 10.1016/s0140-6736(64)92617-0.
3
The bronchoconstrictor action of bradykinin in the guinea-pig.缓激肽在豚鼠体内的支气管收缩作用。
Br J Pharmacol Chemother. 1960 Jun;15(2):290-7. doi: 10.1111/j.1476-5381.1960.tb01247.x.
4
Evidence for an adrenergic homeostatic bronchodilator reflex mechanism.肾上腺素能稳态支气管扩张反射机制的证据。
Eur J Pharmacol. 1967 Dec;2(3):214-23. doi: 10.1016/0014-2999(67)90090-8.
5
The effect of propranolol on airway resistance.普萘洛尔对气道阻力的影响。
Br J Anaesth. 1967 Dec;39(12):919-26. doi: 10.1093/bja/39.12.919.
6
The activities of alpha- and beta-adrenoceptive blocking agents in reducing intestinal relaxation due to sympathetic stimulation in the pithed rat.α-和β-肾上腺素能阻断剂对减轻去大脑大鼠交感神经刺激所致肠松弛的作用。
J Pharm Pharmacol. 1970 Mar;22(3):189-92. doi: 10.1111/j.2042-7158.1970.tb08495.x.
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Thorax. 1969 Sep;24(5):616-8. doi: 10.1136/thx.24.5.616.
8
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9
Selective blockade of adrenoceptive beta receptors in the heart.心脏中肾上腺素能β受体的选择性阻断。
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