普萘洛尔治疗高血压的对照试验。
Controlled trial of propranolol in hypertension.
作者信息
Zacharias F J, Cowen K J
出版信息
Br Med J. 1970 Feb 21;1(5694):471-4. doi: 10.1136/bmj.1.5694.471.
Abstract
A trial of oral propranolol as a hypotensive agent was designed to provide adequate treatment periods. Twenty-eight patients with essential hypertension, with a mean blood pressure of 190/111 mm. Hg, were controlled on 120-320 mg. of propranolol daily. Their mean treated blood pressure was 153/91. They then entered, on a randomized and double-blind basis, a cross-over trial of two 16-week periods, blood pressure being measured fortnightly. Propranolol caused a statistically significant fall in blood pressure when compared with placebo. When propranolol was withdrawn blood pressures rapidly rose to hypertensive levels, though not to untreated levels. No postural hypotension was found, but a small change in blood pressure levels on exercise was noted.
摘要
一项将口服普萘洛尔作为降压药的试验旨在设定足够的治疗周期。28名原发性高血压患者，平均血压为190/111毫米汞柱，每日服用120 - 320毫克普萘洛尔后病情得到控制。他们接受治疗后的平均血压为153/91。然后，他们以随机双盲的方式进入了一个为期两个16周阶段的交叉试验，每两周测量一次血压。与安慰剂相比，普萘洛尔使血压出现了具有统计学意义的下降。停用普萘洛尔后，血压迅速升至高血压水平，不过未升至未治疗时的水平。未发现体位性低血压，但注意到运动时血压水平有微小变化。
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