• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Studies on immunological paralysis. IX. The immunogenicity and tolerogenicity of levan (polyfructose) in mice.免疫麻痹研究。IX. 左聚糖（多聚果糖）在小鼠中的免疫原性和耐受性
Immunology. 1972 Dec;23(6):829-42.
2
Studies on immunological paralysis. X. Cellular characteristics of the induction and loss of tolerance to levan (Polyfructose).免疫麻痹研究。X. 对左聚糖（多聚果糖）耐受性诱导及丧失的细胞特征
Immunology. 1972 Dec;23(6):843-55.
3
Induction of B cell tolerance to polysaccharides by exhaustive immunization and during immunosuppression with cyclophosphamide.通过彻底免疫和在环磷酰胺免疫抑制期间诱导B细胞对多糖的耐受性。
Eur J Immunol. 1974 Sep;4(9):603-8. doi: 10.1002/eji.1830040905.
4
Studies on immunological paralysis. XI. A comparison of the tolerogenicity in vitro of levan and type 3 pneumococcal polysaccharide.免疫麻痹的研究。十一。左聚糖和3型肺炎球菌多糖体外耐受性的比较。
Eur J Immunol. 1973 Aug;3(8):496-502. doi: 10.1002/eji.1830030809.
5
Studies on immunological paralysis. V. The influence of molecular weight on the immunogenicity, tolerogenicity and antibody-neutralizing activity of the 3 pneumococcal polysaccharide.免疫麻痹研究。V. 分子量对3种肺炎球菌多糖的免疫原性、耐受性和抗体中和活性的影响
Immunology. 1971 Sep;21(3):535-46.
6
Immunological paralysis of mice with pneumococcal polysaccharide antigens.用肺炎球菌多糖抗原使小鼠发生免疫麻痹。
Bacteriol Rev. 1971 Sep;35(3):267-89. doi: 10.1128/br.35.3.267-289.1971.
7
Studies on immunological paralysis. VI. Thymic-independence of tolerance and immunity to type 3 pneumococcal polysaccharide.免疫麻痹研究。VI. 对3型肺炎球菌多糖的耐受性和免疫的胸腺非依赖性。
Cell Immunol. 1971 Dec;2(6):614-26. doi: 10.1016/0008-8749(71)90009-8.
8
The immunological properties of haptens coupled to thymus-independent carrier molecules. I. The characteristics of the immune response to dinitrophenyl-lysine-substituted pneumococcal polysaccharide (SIII) and levan.与非胸腺依赖性载体分子偶联的半抗原的免疫学特性。I. 对二硝基苯基赖氨酸取代的肺炎球菌多糖（SIII）和左聚糖的免疫反应特征。
Eur J Immunol. 1974 May;4(5):370-7. doi: 10.1002/eji.1830040513.
9
Regulation of the antibody response to type 3 pneumococcal polysaccharide. IV. Role of suppressor T cells in the development of low-dose paralysis.对3型肺炎球菌多糖抗体反应的调节。IV. 抑制性T细胞在低剂量麻痹形成中的作用。
J Immunol. 1974 Jun;112(6):2020-7.
10
Studies on immunological paralysis. 8. Pneumococcal polysaccharide tolerance and immunity differences between the Biozzi high and low responder lines of mice.免疫麻痹研究。8. 肺炎球菌多糖耐受性以及Biozzi高反应性和低反应性小鼠品系之间的免疫差异。
Eur J Immunol. 1972 Jun;2(3):269-73. doi: 10.1002/eji.1830020315.

引用本文的文献

1
Dissociation of the anti-hapten and anti-carrier responses of mice injected with dinitrophenylated lipopolysaccharide.注射二硝基苯基化脂多糖的小鼠抗半抗原和抗载体反应的解离
Infect Immun. 1981 Jan;31(1):327-33. doi: 10.1128/iai.31.1.327-333.1981.
2
Idiotype-antiidiotype regulation. V. The requirement for immunization with antigen or monoclonal antiidiotypic antibodies for the activation of beta 2 leads to 6 and beta 2 leads to 1 polyfructosan-reactive clones in BALB/c mice treated at birth with minute amounts of anti-A48 idiotype antibodies.独特型-抗独特型调节。V. 对于出生时用微量抗A48独特型抗体处理的BALB/c小鼠，激活β2致6和β2致1多聚果糖反应性克隆需要用抗原或单克隆抗独特型抗体进行免疫。
J Exp Med. 1983 Oct 1;158(4):1129-44. doi: 10.1084/jem.158.4.1129.
3
Allosuppressor and allohelper T cells in acute and chronic graft-vs-host disease. I. Alloreactive suppressor cells rather than killer T cells appear to be the decisive effector cells in lethal graft-vs.-host disease.急性和慢性移植物抗宿主病中的同种抑制性T细胞和同种辅助性T细胞。I. 在致死性移植物抗宿主病中，起决定性作用的效应细胞似乎是同种反应性抑制细胞而非杀伤性T细胞。
J Exp Med. 1982 May 1;155(5):1501-22. doi: 10.1084/jem.155.5.1501.
4
Induction and persistence of B-cell tolerance to the thymus-dependent component of the alpha(1 leads to 6) glucosyl determinant of dextran. Recovery induced by treatment with dextranase in vivo.对葡聚糖α(1→6)葡萄糖基决定簇的胸腺依赖性成分的B细胞耐受性的诱导与维持。体内用葡聚糖酶治疗诱导的恢复。
Immunology. 1981 Nov;44(3):517-27.
5
Cellular requirements for the primary in vitro antibody response to DNP-ficoll.对二硝基苯基-聚蔗糖进行初次体外抗体应答的细胞需求
J Exp Med. 1974 May 1;139(5):1354-60. doi: 10.1084/jem.139.5.1354.
6
Studies on immunological paralysis. X. Cellular characteristics of the induction and loss of tolerance to levan (Polyfructose).免疫麻痹研究。X. 对左聚糖（多聚果糖）耐受性诱导及丧失的细胞特征
Immunology. 1972 Dec;23(6):843-55.
7
The influence of epitope density on the immunological properties of hapten-protein conjugates. II. The in vivo and in vitro metabolism of heavily and lightly conjugated protein.表位密度对半抗原-蛋白质缀合物免疫特性的影响。II. 高度和轻度缀合蛋白质的体内和体外代谢
Immunology. 1974 Oct;27(4):699-710.
8
Non-specific stimulation of immunoglobulin synthesis in mice by capsular polysaccharide of Klebsiella pneumoniae.肺炎克雷伯菌荚膜多糖对小鼠免疫球蛋白合成的非特异性刺激作用。
Immunology. 1974 Aug;27(2):179-93.
9
Mechanism of thymus-independent immunocyte triggering. Mitogenic activation of B cells results in specific immune responses.非胸腺依赖性免疫细胞触发机制。B细胞的促有丝分裂激活导致特异性免疫反应。
J Exp Med. 1974 Jan 1;139(1):74-92. doi: 10.1084/jem.139.1.74.
10
Levan-induced glomerulitis in rabbits: a possible role for direct complement activation in situ.兔中左旋糖酐诱导的肾小球肾炎：原位直接补体激活的可能作用。
Br J Exp Pathol. 1985 Apr;66(2):165-71.

本文引用的文献

1
STUDIES ON GLOBULIN AND ANTIBODY PRODUCTION IN MICE THYMECTOMIZED AT BIRTH.新生期切除胸腺的小鼠球蛋白和抗体生成的研究。
Immunology. 1964 Jul;7(4):419-39.
2
Studies on the capacity of some polysaccharides to elicit antibody formation in man.关于某些多糖在人体内引发抗体形成能力的研究。
J Exp Med. 1957 May 1;105(5):383-94. doi: 10.1084/jem.105.5.383.
3
Synthesis and use of O-stearoyl polysaccharides in passive hemagglutination and hemolysis.O-硬脂酰多糖在被动血凝和溶血中的合成与应用
Eur J Biochem. 1967 Mar;1(1):46-50. doi: 10.1007/978-3-662-25813-2_9.
4
Hemagglutination with aldehyde-fixed erythrocytes for assay of antigens and antibodies.用醛固定红细胞进行血凝反应以检测抗原和抗体。
Proc Soc Exp Biol Med. 1967 Apr;124(4):1166-70. doi: 10.3181/00379727-124-31953.
5
Thymus-marrow cell combinations. Synergism in antibody production.胸腺-骨髓细胞组合。抗体产生中的协同作用。
Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1167-71. doi: 10.3181/00379727-122-31353.
6
Antigens in immunity. VII. Analysis of immunological memory.免疫中的抗原。VII. 免疫记忆分析。
Immunology. 1965 Oct;9(4):333-48.
7
Studies on the cellular basis of IgM immunological memory.IgM免疫记忆细胞基础的研究。
Immunology. 1969 May;16(5):621-32.
8
Thymus dependence of antibody response: variation with dose of antigen and class of antibody.抗体反应的胸腺依赖性：随抗原剂量和抗体类别而变化
Nature. 1968 Nov 30;220(5170):927-8. doi: 10.1038/220927a0.
9
Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.免疫反应中的细胞间相互作用。II. 给受照射小鼠输注骨髓、胸腺或胸导管淋巴细胞后溶血素形成细胞的来源。
J Exp Med. 1968 Oct 1;128(4):821-37. doi: 10.1084/jem.128.4.821.
10
The X-Y-Z scheme of immunocyte maturation. VII. Cell division and the establishment of short-term IgM memory.免疫细胞成熟的X-Y-Z模式。VII. 细胞分裂与短期IgM记忆的建立。
J Exp Med. 1969 May 1;129(5):897-907. doi: 10.1084/jem.129.5.897.

免疫麻痹研究。IX. 左聚糖（多聚果糖）在小鼠中的免疫原性和耐受性

Studies on immunological paralysis. IX. The immunogenicity and tolerogenicity of levan (polyfructose) in mice.

作者信息

Miranda J J

出版信息

Immunology. 1972 Dec;23(6):829-42.

PMID:4405409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1407990/
Abstract

The immunological response to native levan (a fructose homopolymer with molecular weight 2×10) has been studied in (DBA/1×CBA-T6T6)F mice by passive haemagglutination and plaque-forming cell (PFC) assays. It resembles type-specific pneumococcal polysaccharide (SSS) in eliciting a prolonged humoral antibody response over a wide dose range (0.0001–100 μg) and in inducing longlasting `high zone' tolerance with a single injection (1 mg or more). Other similarities include an exclusively IgM response, independence of synergy with thymus-derived lymphocytes and absence of immunological memory. On the other hand, parallelism between serum haemagglutinin and PFC levels following all doses of antigen implies that higher immunizing doses of levan, unlike SSS, do not engage in peripheral neutralization of antibody. It was concluded from studying the fate of C-labelled levan that this was attributable to more rapid elimination from the circulation and subsequent slow metabolism of this polysaccharide. Levan also differs from SSS in inducing tolerance directly, without a detectable prior immune phase.

摘要

通过被动血凝和空斑形成细胞（PFC）试验，在（DBA/1×CBA-T6T6）F小鼠中研究了对天然果聚糖（一种分子量为2×10的果糖同聚物）的免疫反应。它在广泛的剂量范围（0.0001 - 100μg）内引发长时间的体液抗体反应，以及通过单次注射（1mg或更多）诱导持久的“高区”耐受性方面，类似于型特异性肺炎球菌多糖（SSS）。其他相似之处包括仅产生IgM反应、与胸腺来源淋巴细胞协同作用的独立性以及缺乏免疫记忆。另一方面，所有剂量抗原后血清血凝素和PFC水平之间的平行关系表明，与SSS不同，更高免疫剂量的果聚糖不会参与抗体的外周中和。通过研究C标记果聚糖的命运得出结论，这归因于该多糖从循环中更快的清除以及随后缓慢的代谢。果聚糖在直接诱导耐受性方面也与SSS不同，没有可检测到的先前免疫阶段。