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免疫细胞成熟的X-Y-Z模式。VII. 细胞分裂与短期IgM记忆的建立。

The X-Y-Z scheme of immunocyte maturation. VII. Cell division and the establishment of short-term IgM memory.

作者信息

Byfield P, Sercarz E

出版信息

J Exp Med. 1969 May 1;129(5):897-907. doi: 10.1084/jem.129.5.897.

DOI:10.1084/jem.129.5.897
PMID:5305241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2138634/
Abstract

Short-term IgM memory is established within 1 day after primary injection. This 1 day priming is independent of cell division as it can take place in the pressence of methotrexate or hydroxyurea. The primary response involves a similar 1 day nonproliferative phase. On the contrary, cells responding to a second injection of antigen after short priming intervals begin to proliferate within hours. This implies a qualitative difference between the antigen-sensitive cells in primed and normal animals. After 1 day, further proliferative expansion of memory can occur, which is probably antigen dependent. The response to several dose regimens indicates that repeated antigenic contact is needed to maintain the IgM response.

摘要

短期IgM记忆在初次注射后1天内建立。这1天的启动不依赖于细胞分裂，因为它可以在甲氨蝶呤或羟基脲存在的情况下发生。初次反应涉及类似的1天非增殖期。相反，在短时间启动间隔后对第二次注射抗原作出反应的细胞在数小时内开始增殖。这意味着经启动的动物和正常动物体内的抗原敏感细胞存在质的差异。1天后，记忆细胞可进一步发生增殖性扩增，这可能依赖于抗原。对几种给药方案的反应表明，需要反复接触抗原以维持IgM反应。

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本文引用的文献

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THE EFFECT OF DELAYED ADMINISTRATION OF FOLINIC ACID ON IMMUNOLOGICAL INHIBITION BY METHOTREXATE.亚叶酸钙延迟给药对甲氨蝶呤免疫抑制作用的影响。
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IMMUNOGENICITY OF ANTIGEN-CONTAINING RIBONUCLEIC ACID PREPARATIONS FROM MACROPHAGES.来自巨噬细胞的含抗原核糖核酸制剂的免疫原性
Nature. 1965 Jan 30;205:470-4. doi: 10.1038/205470a0.
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A METHOD OF INJECTING SMALL LABORATORY ANIMALS BY THE OPHTHALMIC PLEXUS ROUTE.
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