Shapiro G G, Christie D L
Pediatrics. 1979 Feb;63(2):207-12.
The aims of this study were to evaluate the incidence of gastroesophageal reflux (GER) in chronic allergic steroid-dependent asthmatic children and to assess whether a medical antireflux regimen might improve pulmonary status of asthmatics found to have reflux. Nineteen patients had a determination of lower esophageal sphincter (LES) pressure, pH assessment after acid instillation into the stomach (acid reflux test), and esophagram. After the reflux evaluation, an antireflux regimen was instituted for three weeks; patients were followed with asthma symptom diaries and weekly pulmonary function tests for this period and for another three weeks after finishing the regimen. Gastroesophageal reflux, diagnosed by positive acid reflux test, occurred in nine patients. Five patients had low LES pressure (less than or equal to 12 mm Hg), and two patients had an abnormal esophagram. There were no significant changes in asthma symptoms or pulmonary function tests with the medical antireflux regimen. Although GER does exist in a high percentage of this patient sample (47%), a short-term antacid and positional antireflux regimen does not improve the pulmonary status of these patients.
本研究的目的是评估慢性过敏性激素依赖型哮喘儿童胃食管反流（GER）的发生率，并评估药物抗反流治疗方案是否能改善被发现有反流的哮喘患者的肺部状况。19名患者接受了食管下括约肌（LES）压力测定、向胃内注入酸后的pH评估（酸反流试验）以及食管造影。在反流评估后，实施抗反流治疗方案三周；在此期间以及治疗方案结束后的另外三周，患者记录哮喘症状日记并每周进行肺功能测试。通过酸反流试验阳性诊断为胃食管反流的患者有9名。5名患者LES压力较低（小于或等于12毫米汞柱），2名患者食管造影异常。药物抗反流治疗方案对哮喘症状或肺功能测试没有显著影响。虽然在该患者样本中GER的发生率很高（47%），但短期的抗酸和体位性抗反流治疗方案并不能改善这些患者的肺部状况。
