Euler A R, Byrne W J, Ament M E, Fonkalsrud E W, Strobel C T, Siegel S C, Katz R M, Rachelefsky G S
Pediatrics. 1979 Jan;63(1):47-51.
To evaluate the role of gastroesophageal reflux (GER) as a possible cause of recurrent pulmonary disease, 30 children, aged 1 to 18 years, were studied prospectively with esophageal function tests. These included esophagram (30 patients), esophageal manometry (29 patients), pH probe (Tuttle) test (29 patients), and esophagoscopy with esophageal biopsy (23 patients). The patients studied had either chronic asthma or two or more documented pneumonias within a one-year period. Nineteen (63%) had GER based on two or more positive tests. Eighteen had positive Tuttle tests; 13 had abnormal manometry studies; nine had esophagitis on biopsy; six had esophagitis on esophagoscopy; and five had reflux on esophagram. Of those with GER, 17 had a history of nocturnal cough and eight vomited during infancy. Children with recurrent pulmonary disease should have esophageal function testing to exclude GER as the cause.
为评估胃食管反流（GER）作为复发性肺部疾病可能病因的作用，对30名年龄在1至18岁的儿童进行了食管功能测试的前瞻性研究。这些测试包括食管造影（30例患者）、食管测压（29例患者）、pH探头（塔特尔）测试（29例患者）以及食管镜检查并取食管活检（23例患者）。所研究的患者患有慢性哮喘或在一年内有两次或更多次记录在案的肺炎。基于两项或更多项阳性测试，19例（63%）存在GER。18例塔特尔测试呈阳性；13例食管测压研究异常；9例活检显示有食管炎；6例食管镜检查发现有食管炎；5例食管造影显示有反流。在有GER的患者中，17例有夜间咳嗽史，8例在婴儿期有呕吐。患有复发性肺部疾病的儿童应进行食管功能测试以排除GER作为病因。
