Pilgeram L O, Ellison J, Von dem Bussche G
Br Med J. 1974 Aug 31;3(5930):556-8. doi: 10.1136/bmj.3.5930.556.
Soluble fibrin was measured weekly for two months in 12 normal women and in 12 women on combined oestrogen-progestogen therapy (Ortho-Novin, Norinyl, Enavid, Ovral, Ovulen, Demulen). Plasma soluble fibrin concentration in women on oral contraceptives showed an increase of 97.2% (P <0.001) above that of normal women. In three cases, where each woman on the oral contraceptive served as her own control, stopping medication led to a return to normal of the plasma content of soluble fibrin.
在12名正常女性和12名接受雌激素 - 孕激素联合治疗（炔诺酮炔雌醇片、复方炔诺酮片、炔雌醇甲醚片、复方炔诺孕酮片、复方炔孕酮片、复方甲地孕酮片）的女性中，连续两个月每周测量可溶性纤维蛋白。口服避孕药女性的血浆可溶性纤维蛋白浓度比正常女性高出97.2%（P<0.001）。在3例口服避孕药的女性中，每例女性以自身作为对照，停药后血浆可溶性纤维蛋白含量恢复正常。
