青霉胺对尿中有机汞排泄的选择性增强作用。
Selective enhancement of urinary organic mercury excretion by D-penicillamine.
作者信息
Ishihara N, Shiojima S, Suzuki T
出版信息
Br J Ind Med. 1974 Jul;31(3):245-9. doi: 10.1136/oem.31.3.245.
Abstract
245-249. This report deals with the study of a patient who was suspected of having mercury vapour poisoning and was treated with D-penicillamine. D-penicillamine by mouth enhanced the urinary excretion of organic but not inorganic mercury. It was considered that D-penicillamine was ineffective because at a relatively low dose level of inorganic mercury exposure most inorganic mercury was tightly bound to sites of great affinity for mercury in tissues and resistant to replacement with D-penicillamine. On the contrary, organic mercury was considered to be easily replaced with D-penicillamine. The need to study further the different nature of tissue binding between inorganic and organic mercury is discussed.
摘要
245 - 249。本报告涉及对一名疑似汞蒸气中毒并接受D - 青霉胺治疗患者的研究。口服D - 青霉胺可增加有机汞而非无机汞的尿排泄。据认为，D - 青霉胺无效，因为在相对低剂量的无机汞暴露情况下，大多数无机汞紧密结合于组织中对汞具有高亲和力的位点，且不易被D - 青霉胺取代。相反，有机汞被认为易于被D - 青霉胺取代。文中讨论了进一步研究无机汞与有机汞在组织结合方面不同性质的必要性。
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