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氚标记胆汁酸:问题与建议。

Tritiated bile acids: problems and recommendations.

作者信息

Panveliwalla D K, Pertsemlidis D, Ahrens E H

出版信息

J Lipid Res. 1974 Sep;15(5):530-2.

PMID:4416744
Abstract

Kinetic studies of cholic and chenodeoxycholic acids were carried out in three patients by simultaneous intravenous administration of appropriate pairs of (3)H- and (14)C-labeled compounds. The results obtained indicated two sources of error: chemical impurity and loss of tritium by biological exchange. Precautions are listed for use of tritiated bile acids in studies of pool sizes and turnover rates.

摘要

通过同时静脉注射适当的(3)H和(14)C标记化合物对,对三名患者进行了胆酸和鹅去氧胆酸的动力学研究。所得结果表明存在两个误差来源:化学杂质和生物交换导致的氚损失。列出了在研究池大小和周转率时使用氚标记胆汁酸的注意事项。

相似文献

1
Tritiated bile acids: problems and recommendations.氚标记胆汁酸:问题与建议。
J Lipid Res. 1974 Sep;15(5):530-2.
2
Measurement and validation of human bile salt pool size and synthesis.人体胆盐池大小及合成的测量与验证
Clin Chim Acta. 1974 Dec 17;57(3):239-48. doi: 10.1016/0009-8981(74)90403-3.
3
The fate of labelled bile salts introduced into the colon.引入结肠的标记胆汁盐的去向
Scand J Gastroenterol. 1974;9(1):33-9.
4
Effect of oral chenodeoxycholic acid on bile acid kinetics and biliary lipid composition in women with cholelithiasis.口服鹅去氧胆酸对胆石症女性胆汁酸动力学和胆汁脂质成分的影响。
J Clin Invest. 1973 Nov;52(11):2809-21. doi: 10.1172/JCI107477.
5
Bile salt metabolism in patients with gallstones in functioning gallbladders.有功能胆囊的胆结石患者的胆汁盐代谢
Gut. 1973 Nov;14(11):885-90. doi: 10.1136/gut.14.11.885.
6
Role of gallbladder in gallstone formation.胆囊在胆结石形成中的作用。
Acta Chir Scand. 1974;140(1):45-9.
7
Changes in in vivo metabolism of bile acids in rat after treatment with phenobarbital.苯巴比妥处理后大鼠体内胆汁酸代谢的变化。
Lipids. 1974 Nov;9(11):844-9. doi: 10.1007/BF02532607.
8
The formation of deoxycholic acid and chenodeoxycholic acid in man.人体内脱氧胆酸和鹅脱氧胆酸的形成。
Clin Sci Mol Med. 1974 Feb;46(2):183-90. doi: 10.1042/cs0460183.
9
Effect of ursodeoxycholic acid administration on biliary lipid composition and bile acid kinetics in cholesterol gallstone patients.熊去氧胆酸给药对胆固醇结石患者胆汁脂质成分及胆汁酸动力学的影响。
Dig Dis Sci. 1979 Feb;24(2):123-8. doi: 10.1007/BF01324739.
10
Simultaneous determination of pool sizes and fractional turnover rates, of deoxycholic acid, cholic acid and chenodeoxycholic acid in man by isotope dilution with 2H and 13C labels and serum sampling.通过用2H和13C标记进行同位素稀释以及血清采样同时测定人体中脱氧胆酸、胆酸和鹅去氧胆酸的池大小和分数周转率。
Biomed Environ Mass Spectrom. 1987 Nov;14(11):609-11. doi: 10.1002/bms.1200141106.

引用本文的文献

1
Comparison of bile acid synthesis determined by isotope dilution versus fecal acidic sterol output in human subjects.通过同位素稀释法测定的胆汁酸合成与人类受试者粪便酸性固醇排出量的比较。
Lipids. 1982 May;17(5):345-8. doi: 10.1007/BF02535192.
2
Unreliability of tritiated cholesterol: studies with [1,2-3H]-cholesterol and [24,25-3H]cholesterol in humans.氚标记胆固醇的不可靠性:[1,2-³H] -胆固醇和[24,25-³H] -胆固醇在人体中的研究
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2255-9. doi: 10.1073/pnas.77.4.2255.
3
Evidence for loss of tritium from 3 beta-tritiated deoxycholic acid during enterohepatic cycling in man.
Lipids. 1988 Jun;23(6):629-30. doi: 10.1007/BF02535611.
4
Altered bile acid metabolism in vegetarians.
Am J Dig Dis. 1975 Oct;20(10):935-46. doi: 10.1007/BF01070879.
5
Identification and quantitation of cholanoic acids in hepatic and extra-hepatic tissues of rat.大鼠肝组织和肝外组织中胆烷酸的鉴定与定量分析。
Lipids. 1975 Jun;10(6):340-7. doi: 10.1007/BF02532456.
6
Biosynthesis of chenodeoxycholic acid in man: stereospecific side-chain hydroxylations of 5beta-cholestane-3alpha,7alpha-diol.人体内鹅去氧胆酸的生物合成:5β-胆甾烷-3α,7α-二醇的立体特异性侧链羟基化作用
J Clin Invest. 1978 Sep;62(3):539-45. doi: 10.1172/JCI109158.
7
Exchange of tritium from randomly tritiated taurocholate by microbial bile salt oxidoreductases.微生物胆汁盐氧化还原酶介导的氚从随机氚标记的牛磺胆酸盐中的交换。
Experientia. 1978 Apr 15;34(4):426-7. doi: 10.1007/BF01935902.
8
Convenient non-chromatographic assays for the microbial deconjugation and 7alpha-OH bioconversion of taurocholate.用于牛磺胆酸盐微生物去结合反应和7α-羟基生物转化的便捷非色谱分析方法。
Appl Microbiol. 1975 Oct;30(4):530-5. doi: 10.1128/am.30.4.530-535.1975.