两种新型、直接且特异的酸性磷酸酶测定方法。全国性现场试验。
Two new, direct, and specific methods of acid phosphatase determination. National field trial.
作者信息
Wajsman Z, Chu T M, Saroff J, Slack N, Murphy G P
出版信息
Urology. 1979 Jan;13(1):8-11. doi: 10.1016/0090-4295(79)90003-7.
A national study of the new specific assays for prostatic acid phosphatase was conducted by the National Prostatic Cancer Project. The results of the study have confirmed that the counterimmunoelectrophoretic method is easily reproducible, highly specific, and sufficiently sensitive. Based on tests as performed by different institutions, the counterimmunoelectrophoretic (CIEP) method was also shown to have high reproducibility and was found to be of much greater sensitivity than the conventional biochemical methods for the detection of earlier stages of prostatic cancer. The national study of the radioimmunoassay (RIA) has shown that although being a highly sensitive method, it could not be readily distributed at this time from one specialized center. It requires highly specific, expensive technical assistance and is not yet available nationwide. CIEP is recommended at this time to be used as the preferred method in the evaluation and diagnosis of prostatic cancer. The value of counterimmunoelectrophoresis in detecting early prostatic cancer as a screening method is promising, but still under study.
国家前列腺癌项目开展了一项关于前列腺酸性磷酸酶新特异性检测方法的全国性研究。研究结果证实，对流免疫电泳法易于重复，特异性高且灵敏度足够。根据不同机构的检测，对流免疫电泳（CIEP）法也显示出高重复性，并且发现其在检测前列腺癌早期阶段时比传统生化方法灵敏度高得多。全国性的放射免疫分析（RIA）研究表明，尽管它是一种高灵敏度方法，但目前无法从一个专业中心轻易推广。它需要高度特异性、昂贵的技术支持，且尚未在全国范围内普及。目前建议将CIEP用作评估和诊断前列腺癌的首选方法。对流免疫电泳作为一种筛查方法在检测早期前列腺癌方面的价值很有前景，但仍在研究中。
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