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刚果锥虫感染犊牛的发病机制。V. 组织学定量变化

The pathogenesis of Trypanosoma congolense infection in calves. V. Quantitative histological changes.

作者信息

Valli V E, Forsberg C M

出版信息

Vet Pathol. 1979 May;16(3):334-68. doi: 10.1177/030098587901600307.

DOI:10.1177/030098587901600307
PMID:442464
Abstract

Calves infected with Trypanosoma congolense TREU 112 had generalized microvascular dilation which was most prominent in the liver and the mesentery; there also was increase in cellularity in the lung with significant alveolar thickening and accumulation of hemosiderin-bearing cells in the alveolar septa, focal accumulations of lymphocytes primarily at the corticomedullary junction of the kidneys and a well developed glomerulonephritis, likely membranoproliferative. Reticuloendothelial changes were marrow hyperplasia with an erythroid shift, moderate hemosiderosis and moderate dysthrombopoiesis, marked thymic cortical atrophy, hypersplenism and enlarged nodes with reduced cellular density, paracortical atrophy and medullary sclerosis.

摘要

感染刚果锥虫TREU 112的犊牛出现全身性微血管扩张,在肝脏和肠系膜中最为明显;肺细胞增多,肺泡显著增厚,肺泡隔中有含铁血黄素细胞积聚,淋巴细胞主要在肾皮质髓质交界处局灶性积聚,并伴有可能为膜增生性的严重肾小球肾炎。网状内皮系统变化包括骨髓增生伴红系左移、中度含铁血黄素沉着症和中度血小板生成障碍、明显的胸腺皮质萎缩、脾功能亢进、淋巴结肿大且细胞密度降低、副皮质萎缩和髓质硬化。

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