Gillmer M D, Mazibuko D
Am J Obstet Gynecol. 1979 Mar 1;133(5):499-502. doi: 10.1016/0002-9378(79)90283-7.
Thirteen women with chemical diabetes diagnosed in late pregnancy were found to excrete excessive amounts of urinary xanthurenic acid after a tryptophan load, indicative of a relative pyridoxine (vitamin B6) deficiency. Treatment with 100 mg pyridoxine daily for 14 to 23 days restored the urinary xanthurenic acid excretion to normal in all patients. Improvement of glucose tolerance was observed in only two of the patients studied, deterioration in six, and no significant change in the remaining five. The insulin response to glucose was unaltered during pyridoxine therapy.
13名在妊娠晚期被诊断为化学性糖尿病的女性，在给予色氨酸负荷后，被发现尿中黄尿酸排泄量过多，这表明存在相对的吡哆醇（维生素B6）缺乏。每天用100毫克吡哆醇治疗14至23天，所有患者的尿黄尿酸排泄恢复正常。在研究的患者中，仅2例糖耐量改善，6例恶化，其余5例无明显变化。在吡哆醇治疗期间，胰岛素对葡萄糖的反应未改变。
