Spellacy W N, Buhi W C, Birk S A
Am J Obstet Gynecol. 1977 Mar 15;127(6):599-602. doi: 10.1016/0002-9378(77)90356-8.
Thirteen women with late pregnancy gestational diabetes mellitus were tested with an intravenous glucose tolerance test and both blood glucose and plasma insulin levels were measured. Each woman was then treated with 100 mg. of vitamin B6 per day for 2 weeks and the intravenous glucose tolerance test was then repeated. There was a statistically significant improvement in the glucose tolerance curve after the vitamin B6 treatment, with a lowering of blood glucose levels at all points on the curve except for the 5 minute value. This glucose effect occurred despite an unchanged or lowered plasma insulin level. These results suggest that a relative deficiency in vitamin B6 is associated with some cases of gestational diabetes mellitus and that the replacement of this vitamin improves the metabolic state. The low vitamin B6 levels appear to alter metabolic pathways which result in a lowering of the biologic activity of endogenous insulin.
对13名晚期妊娠糖尿病女性进行了静脉葡萄糖耐量试验，并测量了血糖和血浆胰岛素水平。然后，每位女性每天接受100毫克维生素B6治疗，持续2周，之后重复进行静脉葡萄糖耐量试验。维生素B6治疗后，葡萄糖耐量曲线有统计学意义的改善，除5分钟值外，曲线各点的血糖水平均降低。尽管血浆胰岛素水平未变或降低，但仍出现了这种葡萄糖效应。这些结果表明，维生素B6相对缺乏与某些妊娠糖尿病病例有关，补充这种维生素可改善代谢状态。低水平的维生素B6似乎改变了代谢途径，导致内源性胰岛素的生物活性降低。
