Bennink H J, Schreurs W H
Br Med J. 1975 Jul 5;3(5974):13-5. doi: 10.1136/bmj.3.5974.13.
Fourteen pregnant women were shown by the oral glucose tolerance test to have gestational diabetes. In 13 an increased urinary xanthurenic-acid excretion after an oral load of L-tryptophan indicated a relative pyridoxine deficiency. All patients were treated with vitamin B6 (pyridoxine) 100 mg/day for 14 days by mouth, after which the pyridoxine deficiency disappeared and the oral glucose tolerance improved considerably. Only two patients then had sufficiently impaired glucose tolerance to justify the diagnosis of gestational diabetes; Our results substantiated our hypothesis that increased xanthurenic-acid synthesis during pregnancy may cause gestational diabetes. Treatment with vitamin B6 makes the production of xanthurenic-acid normal by restoring tryptophan metabolism and improves the oral glucose tolerance in patients with gestational diabetes.
口服葡萄糖耐量试验显示，14名孕妇患有妊娠期糖尿病。其中13名孕妇在口服L-色氨酸后尿中黄尿酸排泄增加，提示存在相对的维生素B6缺乏。所有患者口服维生素B6（吡哆醇）100毫克/天，持续14天，之后维生素B6缺乏消失，口服葡萄糖耐量显著改善。只有两名患者的葡萄糖耐量仍有足够损害，符合妊娠期糖尿病的诊断标准；我们的结果证实了我们的假设，即孕期黄尿酸合成增加可能导致妊娠期糖尿病。维生素B6治疗可通过恢复色氨酸代谢使黄尿酸生成正常，并改善妊娠期糖尿病患者的口服葡萄糖耐量。
