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自发性系统性红斑狼疮和类风湿关节炎中的乙酰化酶表型

Acetylator phenotype in spontaneous SLE and rheumatoid arthritis.

作者信息

Lawson D H, Henry D A, Lowe J, Reavey P, Rennie J A, Solomon A

出版信息

Ann Rheum Dis. 1979 Apr;38(2):171-3. doi: 10.1136/ard.38.2.171.

Abstract

Acetylator phenotype was determined in 22 patients with spontaneous systemic lupus erythematosus and the proportion of 'slow' acetylators compared with that obtained in a group of patients with rheumatoid arthritis and a group of healthy controls. 73% of the SLE group were designated 'slow' compared with 72% of the rheumatoid group and 64% of the control group. These differences were not significant.

摘要

对22例自发性系统性红斑狼疮患者进行了乙酰化酶表型测定,并将“慢”乙酰化酶的比例与一组类风湿性关节炎患者和一组健康对照者进行了比较。系统性红斑狼疮组中73%被认定为“慢”乙酰化酶,相比之下,类风湿组为72%,对照组为64%。这些差异并不显著。

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本文引用的文献

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Genetic control of isoniazid metabolism in man.人体中异烟肼代谢的遗传控制。
Br Med J. 1960 Aug 13;2(5197):485-91. doi: 10.1136/bmj.2.5197.485.
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The polymorphic acetylation of dapsone in man.氨苯砜在人体内的多态性乙酰化作用。
Clin Pharmacol Ther. 1971 Mar-Apr;12(2):225-38. doi: 10.1002/cpt1971122part1225.
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Simplified method for determining acetylator phenotype.确定乙酰化酶表型的简化方法。
Br Med J. 1972 Aug 26;3(5825):506-7. doi: 10.1136/bmj.3.5825.506.
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Spontaneous systemic lupus erythematosus and acelylator phenotype.
Acta Med Scand. 1977;201(3):223-6. doi: 10.1111/j.0954-6820.1977.tb15686.x.
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Disease and acetylation polymorphism.疾病与乙酰化多态性
Clin Pharmacokinet. 1977 May-Jun;2(3):182-97. doi: 10.2165/00003088-197702030-00003.

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