Iwamoto T, Jakobiec F A
Arch Ophthalmol. 1979 Jun;97(6):1144-53. doi: 10.1001/archopht.1979.01020010598020.
Capillary and cavernous hemangiomas are often grouped together as if they were modulations of the same entity. To clarify this nosologic question, three capillary hemangiomas in children and four cavernous hemangiomas in adults were studied by transmission electron microscopy. The capillary hemangiomas consisted of two variably admixed zones, solid cellular zones and zones with open vascular lumens. However, both zones had similar organization. Each vascular unit was composed of endothelial cells and pericytes, which persisted in a tumor three years after its clinical appearance. Macrophages and degenerating cells were found in the interstitium and may be related to the clinical feature of partial spontaneous regression. The cavernous hemangiomas had much larger lumens, and wider and more heavily collagenized trabeculae. The vascular walls were created by multilaminar smooth muscle cells. Therefore, capillary hemangioma is completely different from cavernous hemangioma, which resembles a venous tumor.
毛细血管瘤和海绵状血管瘤常被归为一类，仿佛它们是同一实体的不同变体。为了阐明这个分类学问题，我们通过透射电子显微镜对3例儿童毛细血管瘤和4例成人海绵状血管瘤进行了研究。毛细血管瘤由两个不同比例混合的区域组成，即实性细胞区和具有开放血管腔的区域。然而，这两个区域具有相似的组织结构。每个血管单位由内皮细胞和周细胞组成，这些细胞在肿瘤出现临床症状三年后仍持续存在。间质中可见巨噬细胞和退变细胞，这可能与部分自发消退的临床特征有关。海绵状血管瘤的管腔大得多，小梁更宽且胶原化更严重。血管壁由多层平滑肌细胞构成。因此，毛细血管瘤与类似静脉肿瘤的海绵状血管瘤完全不同。
