Paty D W, Mervart H, Campling B, Rand C G, Stiller C R
Can J Neurol Sci. 1974 Nov;1(4):211-3. doi: 10.1017/s0317167100019788.
The histocompatibility antigens (HL-A) have been determined in 100 multiple sclerosis (M.S.) patients and 140 randomly selected controls. In the M.S. group there was a statistically significant increase in the frequency of HL-A 7 and W 18 with an insignificant increase in HL-A 3. The variance from normal HL-A patterns in the M.S. population may play some role in establishing the substrate for this disease. Studies in experimental animals have shown that susceptibility to autoimmune disease and to virus infection is linked to the major histocompatibility locus. This has interesting implications for both the "slow virus" and the "autoimmune" theories of the etiology of multiple sclerosis.
已对100例多发性硬化症（M.S.）患者和140例随机选择的对照者进行了组织相容性抗原（HL-A）测定。在M.S.组中，HL-A 7和W 18的频率有统计学意义的增加，HL-A 3有不显著的增加。M.S.人群中HL-A正常模式的差异可能在该疾病的发病基础形成中起一定作用。对实验动物的研究表明，对自身免疫性疾病和病毒感染的易感性与主要组织相容性位点有关。这对多发性硬化症病因的“慢病毒”和“自身免疫”理论都有有趣的启示。
