Paty D W, Furesz J, Boucher D W, Rand C G, Stiller C R
Neurology. 1976 Jul;26(7):651-5. doi: 10.1212/wnl.26.7.651.
One hundred thirty-six patients with multiple sclerosis and several control groups were studied for measles antibodies using several different antigens. Measles antibodies were higher in the multiple sclerosis population, but siblings also had higher titers than matched and random controls. The elevation in antibody titers (complement fixation) was found in female multiple sclerosis patients and male patients with HL-A types 3, 7, and W-18. Male patients not carrying these HL-A antigens had, as a group, relatively normal antibody levels. These data confirm a familial factor in elevated measles antibody titers. We suggest that HL-A antigens are linked to one of the factors that determines measles antibody titers in multiple sclerosis patients.
对136例多发性硬化症患者和几个对照组使用几种不同抗原研究了麻疹抗体。多发性硬化症患者群体中的麻疹抗体水平较高，但患者的兄弟姐妹的抗体滴度也高于匹配对照组和随机对照组。在女性多发性硬化症患者以及携带HL - A 3型、7型和W - 18型的男性患者中发现了抗体滴度（补体结合）升高。未携带这些HL - A抗原的男性患者群体的抗体水平相对正常。这些数据证实了麻疹抗体滴度升高存在家族因素。我们认为HL - A抗原与决定多发性硬化症患者麻疹抗体滴度的因素之一有关。
