Drachman D A, Davison W C, Mittal K K
Arch Neurol. 1976 Jun;33(6):406-13. doi: 10.1001/archneur.1976.00500060012004.
In order to study a possible hereditary factor leading to multiple sclerosis (MS) susceptibility, histocompatibility (HL-A) types were studied in families where two or more first-degree relatives had MS. Neither the inheritance of a particular parental HL-A chromosome, nor the occurrence of any specific HL-A antigens, could be shown to be necessary or sufficient for the development of MS in family members. The distribution of HL-A chromosomes was essentially the same for affected and unaffected family members. An excess of 3,7 haplotype and W21 antigen was demonstrated, both in affected patients and in unaffected family members, in equal proportions. We conclude that the HL-A chromosome has no direct causal relationship to MS susceptibility, although it may be indirectly associated by population stratification, maternal factors, or some other mechanism.
为了研究可能导致多发性硬化症（MS）易感性的遗传因素，我们对两个或更多一级亲属患有MS的家庭进行了组织相容性（HL-A）类型研究。在家庭成员中，既未发现特定亲代HL-A染色体的遗传，也未发现任何特定HL-A抗原的出现对于MS的发生是必要的或充分的。患病和未患病家庭成员的HL-A染色体分布基本相同。在患病患者和未患病家庭成员中，均以相同比例显示出3,7单倍型和W21抗原过量。我们得出结论，HL-A染色体与MS易感性没有直接因果关系，尽管它可能通过人群分层、母体因素或其他一些机制间接相关。
