Waytz P H, Douglas S D
Arthritis Rheum. 1979 May;22(5):490-4. doi: 10.1002/art.1780220508.
Antibody-dependent cell-mediated cytotoxicity (ADCC) was studied in adult patients with rheumatoid arthritis (RA) and in healthy controls. Three effector cell populations from the peripheral blood were studied which included a mixed mononuclear population, a monocyte-depleted fraction, and a monocyte-enriched fraction. The monocyte-enriched fraction from patients with RA mediated a significantly increased degree of cytotoxicity. Enhanced cytotoxicity was more evident at low effector : target ratios. There was no significant difference in ADCC activity between patient cells and control cells when either the mixed mononuclear population or monocyte-depleted population was studied as effectors. The enhanced effector function of the peripheral blood monocyte in this system may be further indication that mononuclear phagocytes are "activated" in patients with RA.
在成年类风湿关节炎（RA）患者和健康对照者中研究了抗体依赖性细胞介导的细胞毒性（ADCC）。研究了外周血中的三种效应细胞群体，包括混合单核细胞群体、单核细胞耗竭部分和单核细胞富集部分。来自RA患者的单核细胞富集部分介导的细胞毒性程度显著增加。在低效应细胞：靶细胞比例下，增强的细胞毒性更为明显。当将混合单核细胞群体或单核细胞耗竭群体作为效应细胞进行研究时，患者细胞和对照细胞之间的ADCC活性没有显著差异。该系统中外周血单核细胞增强的效应功能可能进一步表明，RA患者的单核吞噬细胞被“激活”。
