Seitz M, Hunstein W
Ann Rheum Dis. 1985 Jul;44(7):438-45. doi: 10.1136/ard.44.7.438.
In patients with rheumatoid arthritis high levels of prostaglandin E1 have been found in the joint fluid, and its increased production by adherent synovial cells and macrophages clearly supports the notion that this arachidonic acid metabolite is involved in the pathology of the disease. Besides its known inflammatory qualities and the suppressive effects on various lymphocyte functions prostaglandin E2 has proved to be an essential cofactor in the secretion of the lymphokine osteoclast activating factor. In this study we have discovered an enhanced release of prostaglandin E1 and thromboxane B2 from a subpopulation of blood monocytes from patients with rheumatoid arthritis and active systemic lupus erythematosus. No correlation between prostanoid release from monocytes and inflammatory activity of the disease was found. However, even monocytes from patients with early stage or mild inflammatory activity displayed a 'stimulated' arachidonic acid metabolism. In contrast only patients with active systemic lupus erythematosus showed in this respect comparable secretory activity or monocytes. Our findings may point to a possible pathogenic role of prostanoids in rheumatoid arthritis, which may also have some implication for the early diagnosis of this disease and for its differentiation from other chronic inflammatory rheumatic conditions.
在类风湿性关节炎患者的关节液中发现了高水平的前列腺素E1，并且贴壁滑膜细胞和巨噬细胞对其产生的增加明确支持了这种花生四烯酸代谢物参与该疾病病理过程的观点。除了其已知的炎症特性以及对各种淋巴细胞功能的抑制作用外，前列腺素E2已被证明是淋巴因子破骨细胞激活因子分泌的必需辅助因子。在本研究中，我们发现类风湿性关节炎和活动性系统性红斑狼疮患者的一部分血液单核细胞中前列腺素E1和血栓素B2的释放增加。未发现单核细胞中前列腺素释放与疾病炎症活动之间的相关性。然而，即使是早期或轻度炎症活动患者的单核细胞也表现出“受刺激的”花生四烯酸代谢。相比之下，仅活动性系统性红斑狼疮患者在这方面表现出与单核细胞相当的分泌活性。我们的发现可能表明前列腺素在类风湿性关节炎中可能具有致病作用，这也可能对该疾病的早期诊断及其与其他慢性炎症性风湿性疾病的鉴别具有一定意义。
