类风湿关节炎患者效应细胞、滑液和血清在抗体依赖性细胞介导的细胞毒性中的行为。
Behaviour of effector cells, synovial fluids, and sera from rheumatoid arthritis patients in antibody-dependent cell-mediated cytotoxicity.
作者信息
Cooke L A, Hay F C, Perumal R
出版信息
Ann Rheum Dis. 1979 Jun;38(3):252-6. doi: 10.1136/ard.38.3.252.
Abstract
Antibody-dependent cell-mediated cytotoxicity (ADCC) was examined in patients with rheumatoid arthritis (RA). The cytotoxicity of peripheral blood leucocytes from patients with RA was similar to that found in normal persons, whereas ADCC was less effective in RA synovial fluid cells. It is possible that the activity in these cells is lower because of immune complexes and other factors being absorbed from the synovial fluid itself. Although patients' sera had little effect on normal peripheral blood leucocytes, synovial fluid from RA patients was markedly inhibitory in ADCC. The degree of inhibition correlated significantly with the clinical status of the patients.
摘要
对类风湿性关节炎（RA）患者进行了抗体依赖性细胞介导的细胞毒性（ADCC）检测。RA患者外周血白细胞的细胞毒性与正常人相似，而ADCC在RA滑膜液细胞中的作用较弱。这些细胞中的活性可能较低，因为免疫复合物和其他因子从滑膜液本身被吸收。尽管患者血清对正常外周血白细胞影响较小，但RA患者的滑膜液在ADCC中具有明显的抑制作用。抑制程度与患者的临床状况显著相关。
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