麸质敏感性肠病：抗麦醇溶蛋白抗体的体外合成
Gluten-sensitive enteropathy: synthesis of antigliadin antibody in vitro.
作者信息
Falchuk Z M, Strober W
出版信息
Gut. 1974 Dec;15(12):947-52. doi: 10.1136/gut.15.12.947.
Abstract
The intestinal mucosa of patients with gluten-sensitive enteropathy responds to gluten challenge in vivo with a striking increase in IgA and IgM synthesis. Whether this increase in immunoglobulin synthesis is due in some part to the production of antigliadin antibodies is examined. Using an affinity chromatography technique it has been demonstrated that in six of seven patients with gluten-sensitive enteropathy approximately half of the net increase in IgA and IgM synthesis occurring after gluten challenge can be attributed to the synthesis of antigliadin antibody. These data strengthen the hypothesis that immunological phenomena are related to the pathogenesis of glutensensitive enteropathy.
摘要
麸质敏感肠病患者的肠黏膜在体内对麸质激发产生反应，IgA和IgM合成显著增加。研究了免疫球蛋白合成的这种增加是否部分归因于抗麦醇溶蛋白抗体的产生。使用亲和层析技术已证明，在7例麸质敏感肠病患者中的6例中，麸质激发后IgA和IgM合成净增加量的约一半可归因于抗麦醇溶蛋白抗体的合成。这些数据强化了免疫现象与麸质敏感肠病发病机制相关的假说。
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