Muller D P, Harries J T, Lloyd J K
Gut. 1974 Dec;15(12):966-71. doi: 10.1136/gut.15.12.966.
The vitamin E status and ease of repletion in groups of children with coeliac disease, intestinal lymphangiectasia, and abetalipoproteinaemia was studied and compared with earlier studies in cystic fibrosis and obstructive jaundice. Each group represents an experimental model in which one of the transport steps involved in the absorption of vitamin E is defective or absent and thus the relative importance of these factors could be determined. Chylomicron formation and an adequate intraluminal concentration of bile salts were found to be the most important factors for the efficient absorption of the vitamin. The results in the five groups of patients have therapeutic implications if it is considered desirable to correct vitamin E deficiency states.
研究了患有乳糜泻、肠淋巴管扩张症和无β脂蛋白血症的儿童群体的维生素E状况及补充的难易程度，并与先前关于囊性纤维化和梗阻性黄疸的研究进行了比较。每组代表一个实验模型，其中维生素E吸收过程中涉及的一个转运步骤存在缺陷或缺失，因此可以确定这些因素的相对重要性。发现乳糜微粒的形成和足够的肠腔内胆汁盐浓度是维生素有效吸收的最重要因素。如果认为纠正维生素E缺乏状态是可取的，那么这五组患者的研究结果具有治疗意义。
